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IRCT20171230038142N8 IRCT 2019-03-16 Esfahan University of Medical Sciences The Effect of Handmade Del Nido Cardioplegia Solution with Handmade St. Thomas Cardioplegia Solution in terms of Quantitative Levels of Cardiac Troponin I and Phosphocreatine kinase MB. A Comparative Study on the Effect of Handmade Del Nido Cardioplegia Solution with Handmade St. Thomas Cardioplegia Solution in terms of Quantitative Levels of Cardiac Troponin I and Phosphocreatine kinase MB in Ventricular Septal Defect Repair in Pediatric Cardiac Surgery. 2019-01-21 anticipated 60 Complete https://irct.ir/trial/38309 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Female or male patients undergoing surgical repair of large-inferior ventricular diarrhea were easily and conveniently distributed in Chamran Hospital in Isfahan. Then they are randomly assigned random allocation and random numbers in two groups of 30, which will be used in a group of St. Thomas's handmade solution and in another group of Del NIDO solution, Blinding description: The samples are not aware of the therapeutic type and only the presenter is aware of the categorization of patients in each treatment group. Because these two solutions are injected during surgery, so patients are unaware of their drug type. 2-3 Ventricular Septal Defect Repair. Intervention 1: Intervention group: Intervention group: 30 patients receiving St. Thomas cardiopulmonary by hand perfringens with a dose of 20 ml per kg and at a temperature of 4 degrees Celsius. This solution is surgically dispensed immediately before injection of the cardioplegia solution sterilized. Then, through a cardioplegia cannula inserted by the surgeon at the root of the aorta, it is injected through the syringe. The injection rate of the cardiopulse solution is 30 to 40 mmHg and during 2 minutes and is controlled by pressure gauge in the injection route. This solution is injected into the patient in a single dose. Intervention 2: Intervention group: Intervention group: 30 patients with cardiogenic cardiopulmonary bypass grafting by perfusion. This solution is a dose of 15 ml per kilogram and a ratio of four crystalloid units at 4 ° C and one unit of complete oxygenated blood. Both solutions are surgically dispensed sterilized immediately after injection of the cardiopulmonary solution. A cardioplegia cannula inserted by the surgeon at the root of the aorta is injected through the syringe. The injection rate of the cardiopulse solution is 30 to 40 mmHg and in the It is in 2 minutes and is controlled by pressure gauge in the injection route. This solution is injected into the patient in a single dose. Yes - There is a plan to make this available What will be shared: All data is unpublished after being unidentifiable and two years after the article is published. When: Two years after the publication and publication of the results. To whom: Assistants and Professors of the Department of Heart Surgery and Circulation Technology. Conditions: To compare the effects of other handmade solutions on the low levels of troponin I and phospho creatine kinase MB with the present results. Where to obtain: Accepting permission from the research vice president of Isfahan University of Medical Sciences. How to obtain: Accepting permission from the research vice president of Isfahan University of Medical Sciences. Comments:
public Hamid Bigdelian
Isfahan University of Medical Sciences, Hezar Jarib Ave.
Isfahan Iran (Islamic Republic of) 81746-73461 +98 316680048 mortezasadeghi16@gmail.com Esfahan University of Medical Sciences scientific Hamid Bigdelian
Isfahan University of Medical Sciences, Hezar Jarib Ave.
Isfahan Iran (Islamic Republic of) 81746-73461 +98 31 3668 0048 mortezasadeghi16@gmail.com Esfahan University of Medical Sciences Iran (Islamic Republic of) Having less than 12 years of age. Parental satisfaction from intervention. no limit 12 years Both Having a history of heart failure. Having a history of myocardial infarction. I23.2 Ventricular septal defect as current complication following acute myocardial infarction Treatment - Surgery Treatment - Surgery Intervention group: Intervention group: 30 patients receiving St. Thomas cardiopulmonary by hand perfringens with a dose of 20 ml per kg and at a temperature of 4 degrees Celsius. This solution is surgically dispensed immediately before injection of the cardioplegia solution sterilized. Then, through a cardioplegia cannula inserted by the surgeon at the root of the aorta, it is injected through the syringe. The injection rate of the cardiopulse solution is 30 to 40 mmHg and during 2 minutes and is controlled by pressure gauge in the injection route. This solution is injected into the patient in a single dose. Intervention group: Intervention group: 30 patients with cardiogenic cardiopulmonary bypass grafting by perfusion. This solution is a dose of 15 ml per kilogram and a ratio of four crystalloid units at 4 ° C and one unit of complete oxygenated blood. Both solutions are surgically dispensed sterilized immediately after injection of the cardiopulmonary solution. A cardioplegia cannula inserted by the surgeon at the root of the aorta is injected through the syringe. The injection rate of the cardiopulse solution is 30 to 40 mmHg and in the It is in 2 minutes and is controlled by pressure gauge in the injection route. This solution is injected into the patient in a single dose. Quantitative Levels of Cardiac Troponin I. Timepoint: Before surgery, six hours and 12 hours after surgery. Method of measurement: Patient blood sample test. Quantitative Levels of Phosphocreatine kinase MB. Timepoint: Before surgery, six hours and 12 hours after surgery. Method of measurement: Patient blood sample test. Esfahan University of Medical Sciences Approved 2019-01-20 Ethics Committee of Isfahan University of Medical Sciences Isfahan University of Medical Sciences, Hezar Jarib Ave. Isfahan Isfehan Iran (Islamic Republic of)