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IRCT20190220042773N1 IRCT 2019-04-09 Islamic Azad University Prophylactic effect of oral Tranexamic Acid on bleeding in knee replacement surgery Prophylactic effect of oral Tranexamic Acid on bleeding in knee replacement surgery 2019-03-16 anticipated 30 Complete https://irct.ir/trial/38322 interventional Randomization: Not randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. 4 Joint knee replacement hemorrhage. Intervention 1: The intervention group: consisted of 15 patients who took oral capsules of 250 mg Tranexamic Acid every 6 hours They used a total of 2 g 2 day before knee replacement surgery. Intervention 2: Control group : included 15 patients candidate knee replacement surgery entered the study according to entry criteria And doing no extra work. No - There is not a plan to make this available Justification or reason for not sharing IPD is Given the importance of protecting the privacy of patients if they hide patient information and merely inform potential cases
public Dr Yousef Kolookhi
Shahrood, University of Blvd., Shahrood Islamic Azad University
Shahrood Iran (Islamic Republic of) 36199-43189 +98 23 3239 0077 dryousefkolookhianestezi@gmail.com Islamic Azad University scientific Dr Yousef Kolookhi
Shahrood, University of Blvd., Shahrood Islamic Azad University
Shahrood Iran (Islamic Republic of) 36199-43189 +98 23 3239 0077 dryousefkolookhianestezi@gmail.com Islamic Azad University Iran (Islamic Republic of) The patient's full conditions for participation in the study and signature of the prepared form of the informed consent A person with a history of specific disease, such as kidney disease, liver disease, history of ischemia, heart, hypertension, history of self-sacrifice and signs of disability in the diagnosis and treatment of disability. Patients do not use aspirin or any other anticoagulants from the week before surgery: Plavix, heparin, enoxaparin, and warfarin. Do not observe a specific diet (it's not just herbivorous or meat-eaters, or the use of certain substances that lower blood glucose levels) Do not use special medication such as iron or other medications associated with bleeding. no limit no limit Both Patient dissatisfaction to continue participation Patients with abnormal clotting parameters (PT, PTT, BT, INR, platelet) People with high systolic blood pressure (185 in surgery day) During surgery and up to 6 hours after the operation, the osmotic arterial pressure is more than 20%. Patients with complications such as nausea and vomiting, color blindness, headache and dizziness, thromboemboli, myocardial ischemia and nutritional ischemia before and after surgery. Prevention Prevention The intervention group: consisted of 15 patients who took oral capsules of 250 mg Tranexamic Acid every 6 hours They used a total of 2 g 2 day before knee replacement surgery. Control group : included 15 patients candidate knee replacement surgery entered the study according to entry criteria And doing no extra work Volume of bleeding in knee replacement surgery. Timepoint: During surgery and 6 hours after surgery and 12 hours after knee replacement. Method of measurement: Level of hemoglobin and platelets, PT, PTT, BT before and after the operation, the amount of blood lost through surgical suction bottles, weighing the used gauzes during surgery and blood on the field of postoperative surgery patients. Islamic Azad University Approved 2019-03-09 Ethics Committee of Islamic Azad University, Shahrood Branch Shahrood, Shahr Branch, Islamic Azad University, Shahr Shahrood Semnan Iran (Islamic Republic of)