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IRCT20131229015975N5 IRCT 2019-09-05 Esfahan University of Medical Sciences Effect of dorzolamide drop with intravitreal avastin injection in decreasing central macular thickness Effect of dorzolamide drop with intravitreal avastin injection in decreasing central macular thickness in diabetic patient with diabetic macular edema 2017-09-23 anticipated 16 Complete https://irct.ir/trial/38530 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients were selected in a non-probable manner, but the patients' eyes were randomly assigned to two groups of intervention and control based on the lottery, Blinding description: Each eye was randomly assigned to receive one group of the medication. All preparations were individually prepared for each patient and patients and investigators were kept blinded to the randomized allocation and details of series of the medications throughout the study. 2-3 Edema macula. Intervention 1: Intervention group: 16 diabetic patients with elevated double-walled macular thickness in one eye randomly selected in addition to intravascular injection of Avastin at baseline and 1 month later, Dorzolamide topical drops were dropped every 1 to 12 hours and continued for 2 months. Found. Intervention 2: Control group: 16 diabetic patients with bilateral double-blind macular thickness in one eye randomly selected, in addition to intravascular injection of avastin at the start of treatment, and 1 month later, artificial tear drop was dropped every 1 to 12 hours and continued for 2 months. Yes - There is a plan to make this available What will be shared: All information is unpublished after being denied and two years after the publication of the article. When: two years after the publication of the article To whom: Medical students and professors and specialized assistants of the ophthalmology group. Conditions: To compare existing information with similar results at another time or other implementation. Where to obtain: Send a request for cooperation to fazel43@yahoo.com and get permission from the Research Vice-Dept of Isfahan University of Medical Sciences. How to obtain: Send a request for cooperation to fazel43@yahoo.com and get permission from the Research Vice-Dept of Isfahan University of Medical Sciences. Comments:
public Dr. Mohsen Pourazizi
Feiz Hospital
Isfahan Iran (Islamic Republic of) 81746-73461 +98 31 3445 2031 m.pourazizi@yahoo.com Esfahan University of Medical Sciences scientific Farhad Fazel
Isfahan University of Medical Sciences, Hezar Jarib Ave.
Isfahan Iran (Islamic Republic of) 81746-73461 +98 31 3668 0048 fazel43@yahoo.com Esfahan University of Medical Sciences Iran (Islamic Republic of) Diabetic patients with retinopathy who have macular edema due to increased macular thickness or vision loss are indicative of anti-VEGF treatment. A transparent mediator for a thorough examination Visual activity of both eyes are better than 1/10 and less than 4/10 Patient consent to Participate in the Study The thickness of the central area of the macula at the start of treatment is greater than 300 microns 18 years 62 years Both History of bone surgery The presence of atrophy, scarring, fibrosis and hard exudates in the macular center that affects visual acuity. Uncontrolled blood pressure Presence of active eye infectious disease There are other complications of diabetes in the eyes, which leads to an increase in the thickness of the macula. The presence of other synchronous eye pathologies such as glaucoma and cataracts. H58.8 Other specified disorders of eye and adnexa in diseases classified elsewhere Treatment - Other Treatment - Other Intervention group: 16 diabetic patients with elevated double-walled macular thickness in one eye randomly selected in addition to intravascular injection of Avastin at baseline and 1 month later, Dorzolamide topical drops were dropped every 1 to 12 hours and continued for 2 months. Found. Control group: 16 diabetic patients with bilateral double-blind macular thickness in one eye randomly selected, in addition to intravascular injection of avastin at the start of treatment, and 1 month later, artificial tear drop was dropped every 1 to 12 hours and continued for 2 months. Visual activity. Timepoint: Before and two months after the intervention. Method of measurement: Examination by ophthalmologist. Foie thickness. Timepoint: Before and two months after the intervention. Method of measurement: Optical Coherence Topography and Examination by ophthalmologist. Macular volume. Timepoint: Before and two months after the intervention. Method of measurement: Optical Coherence Topography and Examination by ophthalmologist. Esfahan University of Medical Sciences Approved 2017-09-22 Ethics Committee of Isfahan University of Medical Sciences Isfahan University of Medical Sciences, Hezar Jarib Ave. Isfahan Isfehan Iran (Islamic Republic of)