IRCT20110528006617N3 IRCT 2019-05-06 Esfahan University of Medical Sciences The Effect of Dexmedetomidine and Midazolam on Hemodynamic Indices During Anesthesia Evaluation and comparison of hemodynamic indices during head holding pinning in neurosurgery procedures in two groups receiving Dexmedetomidine and Midazolam (Isfahan, 1397) 2018-08-23 anticipated 70 Complete https://irct.ir/trial/38533 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Individuals selected in this trial are sequentially divided into two groups of D and M by randomized block method. Group M received Midazolam and the D group received Dexmedetomidine during anesthesia, Blinding description: Patient information is hidden by the operating room nurse and injectable drugs are also provided to the physician in similar syringes by an anesthetic technician, while the physician will not have any knowledge concerning the substance in the syringe. In addition, the participants will not be informed about the injectable drugs in each syringe and the names of the operating room personnel. 2-3 General Anesthesia. Intervention 1: The first intervention group(Dexmedetomidine): Initially, for primary anesthetic, patients receive 2 mg / kg of propofol and 0.5 microgram per kilogram of atherocorum and fentanyl is injected at 3 micrograms per kg of body weight.To maintain anesthesia, they are given a dose of 1mg per kg body weight / hour of doses of dexmedetomidine. Intervention 2: The second intervention group (midazolam): Initially, for primary anesthetic, patients receive 2 mg / kg of propofol and 0.5 microgram per kilogram of atherocorum and fentanyl is injected at 3 micrograms per kg of body weight. To maintain anesthesia, they use Midazolam infusion at a dose of 0.6 mg / kg body weight per hour. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No further information is available.