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IRCT20190315043057N1 IRCT 2019-04-17 Yazd University of Medical Sciences Evaluation of synergism of prilocaine and lidocaine in local anesthesia in patients with irreversible palpitis Evaluation of synergism of prilocaine and lidocaine in local anesthesia in patients with irreversible palpitis 2019-04-08 anticipated 60 Complete https://irct.ir/trial/38694 interventional Randomization: N/A, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Blinding description: After the first injection with lidocaine anesthesia, in the first patient, the second injection is done using the heads or tails method, One of the anesthetics of perylocaine or lidocaine is chosen as second anesthetic solution. In all odd number sample cases, this anesthetic solution (perlucaine or lidocaine) and for all cases with even number, other anesthetic solution are selected as the second anesthetic solution. 3 Irreversible Pulpits. Intervention group: The group whose second anesthesia is a Perilocaine solution. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Timing Issue

public Seyed Jalil Modaresi

Bahonar Suare- Shahi dadoghi Dental University

Yazd Iran (Islamic Republic of) 8916978477 +98 35 3763 3733 j.modaresi@ssu.ac.ir Yazd University of Medical Sciences scientific Seyed Jalil modaresi

Bahonar Suare- Shahi dadoghi Dental University

Yazd Iran (Islamic Republic of) 8916978477 +98 35 3726 3733 j.modaresi@ssu.ac.ir Yazd University of Medical Sciences Iran (Islamic Republic of) Mandibular molar teeth with irreversible pulpitis The teeth can be restoreable Tooth apex is closed (age +18) The patient who has normal intelligence and are able to meet the critical tests 18 years no limit Both Patients with systemic problems that have a contraindication for lower alveolar block injections, such as those with hemorrhagic problems A history of allergy to local anesthetics of dentistry Use of the medication 24 hours before local anesthetic injection Patients that have a contraindications for use of any of the drugs used in the study (epinephrine, lidocaine, perilocaine) Disturbance in vital signs of the patient after local anesthetic injection Tooth with severe periodontal disease A teeth with sensitivity to percussion or has periapical pathological symptoms in radiography The absence of a healthy tooth or a teeth with small restoration on the opposite side as a control tooth During the study, patient dissatisfaction and announced withdrawal Treatment - Drugs Intervention group: The group whose second anesthesia is a Perilocaine solution Depth of local anesthesia. Timepoint: 10 min after injection of local anesthesia. Method of measurement: Using pulse electric tester, cold test and patient response to the VAS chart. Yazd University of Medical Sciences Approved 2018-11-04 National Ethics Committee for Biomedical Research Bahonar Square- Shahid sadoghi medical university central park Yaz Yazd Iran (Islamic Republic of)