IRCT138706121187N1 IRCT 2010-01-09 Mashhad University of Medical Sciences The Pattern of Opioid Withdrawal Signs and Symptoms in Three Groups The Pattern of Opioid Withdrawal Signs and Symptoms in Three Groups: 1. Patients undergoing Clonidine Abstinence Therapy, 2. Patients on starting clinical dose of Methadone Maintenance Therapy (MMT), and 3. Patients admitted for short-time detoxification with Methadone in Opioid Addict Subjects who were Referred to Imam-Reza Hospital Rehabilitation Center and Toxicology Ward – Mashhad from November 2008 to October 2009 2008-11-21 anticipated 90 Complete https://irct.ir/trial/387 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Opioid Addiction. Intervention 1: In the first group, patients are given Clonidine 0.1 mg per oral q 12 hours, Benzodiazepine (Chlorodiazepoxide 10mg at 6 Am, 10 mg at 2 Pm and 20 mg at 10 Pm per oral), Indomethacin 100 mg if necessary, Omeprazole 1 mg per oral before eating breakfast, Ibuprofen 400 mg q 12 hours per oral, with Risperidone 1 mg daily, and with or without Gabapentin and if needed Serum and Vitamin C in a 10 day period of time. Intervention 2: Patients on Methadone Maintenance Therapy (MMT) for 45 days, are given Methadone 40 mg per oral in the first day and then this dose will be increased 5 mg daily for disappearing the withdrawal signs and symptoms at most until the 10th day and then this dose will gradually be reduced to zero until the end of the 45 day period, pain killer (NSAIDs (Indomethacin 100 mg if necessary) ) in the first ten days and also MOM syrup 10 cc q 8 hours per oral. Intervention 3: The patients in the third group, are given Methadone 10 mg in the first day, 5 mg in the second and third day and nothing in the forth and fifth day, and also Maintenance serum of ⅓⅔ 2 Lit daily IV if necessary,Clonidine 0.1 mg per oral q 12 hours, Chlorodiazepoxide 10mg at 6 Am, 10 mg at 2 Pm and 20 mg at 10 Pm per oral, Indomethacin 100 mg if necessary, Omeprazole 1 mg per oral before eating breakfast, Ibuprofen 400 mg q 12 hours per oral, with Risperidone 1 mg daily.