IRCT20190410043237N1 IRCT 2019-04-23 Mashhad University of Medical Sciences The effect of oral and sublingual and buccal Misoprostol on induction of preterm premature rupture of membrane Comparison of the effects of oral and sublingual and buccal Misoprostol on induction of preterm premature rupture of membrane 2019-05-22 anticipated 120 Complete https://irct.ir/trial/38808 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In envelope method, envelopes with random numbers are prepared and printed with the help of ''Randomize.com'' website. Envelopes are sealed and their contents are not visible from the outside. Firstly, the purpose of the study is explained to the individuals who meet the mentioned conditions. If willing, he/she signs the informed consent form and takes an envelope and opens it and based on its content, will enter either the intervention or control group. 3 Preterm premature rupture of the membranes. Intervention 1: Intervention group: prescribing 50 μg of oral Misoprostol (one fourth of 200-μg misoprostol poduced by SAMISAZ pharmaceutical company) every 4 hours up to a maximum of 6 doses. Intervention 2: Intervention group2: prescribing 25 μg of buccal Misoprostol up to a maximum of 6 doses. Intervention 3: Control group: prescribing 25 μg of sublingual Misoprostol every 4 hours. Yes - There is a plan to make this available What will be shared: All data can be shared after patients are made unidentifiable. When: Data can be accessible 6 months after results are published. To whom: Data will be available for researchers in universities and other scientific institutes. Conditions: Carrying out analysis on data is permitted. Where to obtain: Data can be accessible through sending an email to the corresponding author. How to obtain: After sending a request email to the corresponding author, data will be sent in 1 month. Comments: