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IRCT20190410043236N1 IRCT 2019-07-08 Zanjan University of Medical Sciences Effect of vitamin D on improvement of left ventricular ejection fraction in patients with systolic heart failure Effect of vitamin D on improvement of left ventricular ejection fraction in patients with systolic heart failure 2016-05-02 anticipated 80 Complete https://irct.ir/trial/38837 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: In present study, simple randomization method was used, Blinding description: This double-blind study was carried out and the cardiologist who do echocardiography patients, as well as those taking medication or placebo, are blind. 2-3 Condition 1: Systolic Heart failure. Condition 2: Systolic Heart failure. Intervention 1: Intervention group: Intervention group: A 50000 unit capsule of vitamin D, manufactured by Abidi company, is given weekly and at 50,000 units for 8 weeks. It should be noted that patients will not be aware of the type of medicine. Patients are monitored for 2 months. Intervention 2: Placebo group: Appearance of 50,000 capsules of vitamin D, manufactured by Abidi company, is given weekly for 8 weeks. It should be noted that patients will not be aware of the type of medicine. Patients are monitored for 2 months. Yes - There is a plan to make this available What will be shared: Data files related to the use of medication and medication are also the main implications of sharing. When: The beginning of the access period was 1 year after the publication To whom: Data and other study documentation will be available to all individuals and academic and non-academic institutions. Conditions: Individuals with data receiving conditions can have the data available after receiving the documented consent of Zanjan University of Medical Sciences Where to obtain: Visit Zanjan University of Medical Sciences at your personal or e-mail address and get consent for received information. How to obtain: Individuals or institutions, in person or by email, with his introduction and explanation of the purpose of the visit to the Zanjan University of Medical Sciences has the opportunity to have information and can have information within about 1 month. Comments:
public Dr. Reza Hassanzadeh Makuei
Ayatollah Mousavi Hospital-Gawazang Road
Zanjan Iran (Islamic Republic of) 5235255225 +98 24 3353 4019 makuei42@yahoo.com Zanjan University of Medical Sciences scientific Dr. Reza Hassanzadeh Makuei
Ayatollah Mousavi Hospital-Gavazang Road
Zanjan Iran (Islamic Republic of) 5225665855 +98 24 3353 4019 makuei42@yahoo.com Zanjan University of Medical Sciences Iran (Islamic Republic of) Chronic heart failure with 20%≤EF≤45% (based on Framingham criteria, NYAH Class I, II, III) The level of 25 (OH) Vit D is less than 30 ngr / dl Age over 40 years 40 years no limit Both Hypercalcemia Osteomalacia Taking corticosteroid medication 130-152 150.1 IX Diseases of the circulatory system Left ventricular failure Treatment - Drugs Treatment - Drugs Intervention group: Intervention group: A 50000 unit capsule of vitamin D, manufactured by Abidi company, is given weekly and at 50,000 units for 8 weeks. It should be noted that patients will not be aware of the type of medicine. Patients are monitored for 2 months. Placebo group: Appearance of 50,000 capsules of vitamin D, manufactured by Abidi company, is given weekly for 8 weeks. It should be noted that patients will not be aware of the type of medicine. Patients are monitored for 2 months. Ejection Fraction. Timepoint: Before beginning the intervention with vitamin D and placebo and then 2 months after the intervention. Method of measurement: Echocardiography. End Diastolic Volume. Timepoint: Before beginning the intervention with vitamin D and placebo and then 2 months after the intervention. Method of measurement: Echocardiography. Heart Failure Class. Timepoint: Before beginning the intervention with vitamin D and placebo and then 2 months after the intervention. Method of measurement: Echocardiography. Vitamin D. Timepoint: Before the intervention, then two months after the intervention with vitamin D and placebo. Method of measurement: High Performance Liquid Chromatography. Albumin. Timepoint: Before the intervention, then two months after the intervention with vitamin D and placebo. Method of measurement: Immunoassay. Creatinine. Timepoint: Before the intervention, then two months after the intervention with vitamin D and placebo. Method of measurement: Immunoassay. Calcium. Timepoint: Before the intervention, then two months after the intervention with vitamin D and placebo. Method of measurement: Ion Selected (Specific) Electrode. Phosphor. Timepoint: Before the intervention, then two months after the intervention with vitamin D and placebo. Method of measurement: Ion Selected (Specific) Electrode. Zanjan University of Medical Sciences Approved 2016-04-14 Zanjan University of Medical Sciences Ethics Committee Azad Blv.- Headquarters of Zanjan University of Medical Sciences Zanjan Zanjan Iran (Islamic Republic of)