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IRCT20190411043239N1 IRCT 2019-05-24 Shiraz University of Medical Sciences Comparison of the two methods: using custodiol versus combined custodiol and modified delnido on myocardial protection in Cardiac surgeries. Comparison of the two methods: using custodiol versus combined custodiol and modified delnido on myocardial protection in Cardiac surgeries. 2019-06-20 anticipated 40 Complete https://irct.ir/trial/38899 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: According to the randomized chart which was derived from www.randomization.org, Blinding description: The patient and anesthesia nurse who takes venous blood samples in the operating room.and also the nurse who takes the second and third samples in the ICU and the laboratory instructor does not know the type of patient group. The only person who is aware of the study group is perfusionist who is injected a cardioplegia solution. 2-3 artarteriosclerosis. Intervention 1: Intervention group 1:.Patients in the intervention group one will receive 15 cc per /kg of cold modified delnido cardioplegia solution with 1000 cc custodiol during 2-4 min with anti-grade method. Intervention 2: intervention group2: Patients in the intervention group two will receive 20 cc per/ kg cold custodiol solution during 6-8 min with anti-grade method. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is number of sample size
public Neda reihanifard
Anesthesiology Department, Faghihi Hospital, Zand Street
Shiraz Iran (Islamic Republic of) 7189656948 +98 71 3620 3853 nedaaa.reihanifard@gmail.com Shiraz University of Medical Sciences scientific Mohamad hasan Nemati
Faghihi Hospital, Zand Street
Shiraz Iran (Islamic Republic of) 7189656948 +98 71 3484 4119 nemati_mhs@yahoo.com Shiraz University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Patients under coronary artery bypass graft with ejection fraction below 30 % Redo coronary artery bypass graft surgeries Coronary artery bypass graft surgery with valve surgery no limit no limit Both Emergency surgery Recently myocardial infarction Renal failure I25.10 Atherosclerotic heart disease of native coronary artery without angina pectoris Prevention Prevention Intervention group 1:.Patients in the intervention group one will receive 15 cc per /kg of cold modified delnido cardioplegia solution with 1000 cc custodiol during 2-4 min with anti-grade method intervention group2: Patients in the intervention group two will receive 20 cc per/ kg cold custodiol solution during 6-8 min with anti-grade method. Serum level of CK_MB. Timepoint: induction time, 2 h after operation and 48 h after operation. Method of measurement: venus blood sample. Serum level of Troponin. Timepoint: induction time, 2 h after operation and 48 h after operation. Method of measurement: venus blood sample. Cardiac dysrythmia. Timepoint: induction time, 2h after operation and 48 h after operation. Method of measurement: monitoring. Shiraz University of Medical Sciences Approved 2019-02-20 Ethics committee of Shiraz University of Medical Sciences Vice Chancellor of research, Shiraz University of Medical Sciences, 7th floor, central building of Shiraz University of Medical Sciences, Zand street Shiraz Fars Iran (Islamic Republic of)