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IRCT20190318043088N1 IRCT 2019-04-22 Tehran University of Medical Sciences Comparison of the effect diphenhydramine with injectable lidocaine in median nerve block Comparison of the effect of diphenhydramine with injectable lidocaine in median nerve block in patients coming to Imam Khomeini emergency department 2018-07-26 anticipated 204 Complete https://irct.ir/trial/38927 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Randomization description: Selection of the sample is based on the method of the random block. Thus, the first group, A, the second group, B and the third group, C are considered based on the blocks designed and the following 25 blocks 6 randomly selected from the blocks below, all patients from the number 1 Up to 204 are coded according to one of three words A, B or C. The coding is done randomly by the supervisor of the design, and the project manager, the patient and the analyst of the results of the codes do not know anything about codes. ABABCC/AABCBC/ABBCAC/AACBCB/CCAABB/CCBBAA/CABACB/BBAACC/CBCBAA/ABCABCCABCAB/BBCCAA/ACBACB/CABCAB/BBCACA/CAABBC/CABCBA/ACBBCA/BACBAC /AABBCC, Blinding description: In this study, the researcher, manager, nurses and the data analyzer are kept blindness. Totally there are three groups. The first group will receive lidocaine 1%, the second group receive diphenhydramine 1% and the third group will receive diphenhydramin 0.5%. The method of blinding is triple blinding. The researcher inject medicine blindly. The medications will be prepared by the supervisor of project and taken to similar syringes and given to the assistant with A, B and C. 3 Hand laceration. Intervention 1: Control group: Those who receive lidocaine 1%, 3 milliliter, one time, injection, manufacturing factory Caspian. Intervention 2: The first intervention group: Those who receive diphenhydramine 1%. , 3 milliliter, one time, injection, manufacturing factory Caspian. Intervention 3: The second intervention group: Those who receive diphenhydramine 0.5%. , 3 milliliter, one time, injection, manufacturing factory Caspian. Yes - There is a plan to make this available What will be shared: The total individual data of the participants will be shared after being unidentifiable. When: Six months after publishing results To whom: Doctors, dentists and researchers working in universities and academic institutes Conditions: If someone wants to do a research related to this study, he or she can use documentation with the ethical requirements Where to obtain: Applicants can receive documentation from the author of the article through this email: faribayazdan@yahoo.com How to obtain: Applicants should refer to emergency department of Imam Khomeini hospital with identification card. And after confirmation, they can apply in writing. Then documentation will send them through email. Comments:
public Fariba Yazdanbakhsh
Doctor Gharib Ave., The end of Keshavarz Blvd.
Tehran Iran (Islamic Republic of) 1419733141 +98 21 6656 1838 faribayazdan@yahoo.com Tehran University of Medical Sciences scientific Fariba Yazdanbakhsh
Doctor Gharib Ave., The end of Keshavarz Blvd.
Tehran Iran (Islamic Republic of) 1419733141 +98 21 6656 1838 faribayazdan@yahoo.com Tehran University of Medical Sciences Iran (Islamic Republic of) The patients coming to the emergency with hand laceration from 16 to 65 years 16 years 65 years Both The patients under the age of 16 and over 65 People who are allergic to diphenhydramine or lidocaine or they had conractagonism for lidocaine or diphenhydramine Patients who had received any systemic pain killer patients who had received MAO inhibitor S64.1 Injury of median nerve at wrist and hand level Treatment - Drugs Treatment - Drugs Treatment - Drugs Control group: Those who receive lidocaine 1%, 3 milliliter, one time, injection, manufacturing factory Caspian The first intervention group: Those who receive diphenhydramine 1%. , 3 milliliter, one time, injection, manufacturing factory Caspian The second intervention group: Those who receive diphenhydramine 0.5%. , 3 milliliter, one time, injection, manufacturing factory Caspian ِDuration of medicine effect. Timepoint: After the injection of the medicine when the anesthetic begins until the anesthetic ends. Method of measurement: Chronometer. Onset of action of medicine. Timepoint: Immediately after the injection of the medicine. Method of measurement: Chronometer. Side effects of medicine. Timepoint: After injection. Method of measurement: Patient Clinic and Previous Studies. The amount of pain. Timepoint: While injecting medicine. Method of measurement: Visual analog scale. Tehran University of Medical Sciences Approved 2018-07-22 Ethics committee of Imam Khomeini hospital complex, Tehran university of Medical Sciences Doctor Gharib Av., the end of Keshavarz Blvd. Tehran Tehran Iran (Islamic Republic of)