IRCT20100607004113N18 IRCT 2020-04-18 Tabriz University of Medical Sciences Effect of Palliative Care protocol on mortality and morbidity of Extremely Low Birth Weight Infants Early outcome of Extremely Low Birth Weight Infants before and after Establishment of Palliative Care protocol according to Clinical Risk Index for Babies scoring system (CRIB II) 2020-01-10 anticipated 80 Complete https://irct.ir/trial/38963 interventional Randomization: Not randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Blinding description: research nurse who are blinded to groups . Analyzer of the data also will be blind to the groups of infants. N/A Extreme immaturity of newborn. Intervention 1: Preterm infants in two parallel groups include in the non randomized study , Intervention group are infants who have score of 15 or more according to Clinical Risk Index for Babies scoring system (CRIB II) .After consent of the parents This group of patients will receive palliative care consist of :thermal stabilization ,respiratory support as Nasal Continues Positive Airway Pressure , use of intravenous antibiotics consist of Ampicillin and Gentamicin( according to the guideline of the unit) and Total Parenteral Nutrition. Intervention 2: Control group: are preterm infants who have score of less than 15 according ( CRIB II )scoring system .This group of infants will receive full support care consist of : thermal stabilization ,respiratory support as Nasal Continues Positive Airway Pressure and Mechanical ventilation if needed , use of intravenous antibiotics consist of Ampicillin and Gentamicin( according to the guideline of the unit) , Total Parenteral Nutrition and Surfactant therapy. No - There is not a plan to make this available Justification or reason for not sharing IPD is This study is in the first steps and may be repeated in other centers without ethical considerations