IRCT20190429043416N1 IRCT 2019-06-22 Tehran University of Medical Sciences Evaluation of Erythropoietin's effect in patients consciousness Evaluation of Erythropoietin's effect in patients consciousness with severe Traumatic Brain Injury 2019-02-14 anticipated 18 Complete https://irct.ir/trial/39141 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: In this study Simple Randomization is used for random allocation of samples.For this purpose,referring to Web Site: www.graphpad/quickcalcs/, we use Random Allocation Software for randomization in two groups trial. Sample allocation order is as follows: B=1, A=2, B=3, B=4, A=5, B=6, B=7, A=8, A=9, A=10, B=11, A=12, B=13, B=14, A=15, B=16, A=17, A=18, Blinding description: This study is Double blinded. Patients, clinical nurses, researcher and physicians being kept blinded. 3 Traumatic Brain Injury. Intervention 1: Intervention group: After 24 hours of brian injury 40000 unit of Erythropoietin Ampule via intravenous pathway is injected and patients receive 8000 unit of Erythropoietin intravenously daily until two weeks. Each Erythropoietin Ampule contains 4000 uint (0/5 mililiter) which is prepared from Pooyesh Daru Factory. Intervention 2: Control group:Patients receive 1 mililiter of Normal Saline daily intravenously as Placebo. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Our data will be published as a randomised clinical trial.