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IRCT20141127020112N9 IRCT 2019-06-16 Iran University of Medical Sciences Efficacy of premedication with dextromethorphan and gabapentin alone or in combination for postoperative pain management in ligament of knee surgery Efficacy of premedication with dextromethorphan and gabapentin alone or in combination for postoperative pain management in ACL and PCL knee arthroscopy with general anesthesia 2017-09-01 anticipated 114 Complete https://irct.ir/trial/39204 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: use the random number table, Blinding description: With the cooperation of the pharmaceutical company the drug Gabapentin and Dextromethorphan and the combination of these two were dissolved in the same volume and shape and color and based on the numbers the patients were given an oral dose one hour before surgery. The patients and the donor did not know which group were. 3 Efficacy of premedication with dextromethorphan and gabapentin alone or in combination for postoperative pain management in ACL and PCL knee arthroscopy with general anesthesia. Intervention 1: Intervention group 1 : 100 mg oral Gabapentine, 1hour before surgery. Intervention 2: Intervention group 2: 1mg/kg oral Dextromethorphan 1hour before surgery. Intervention 3: Intervention group 3: 100 mg oral Gabapentine and 1mg/kg oral Dextromethorphan compound soluble in water, 1hour before surgery. Yes - There is a plan to make this available What will be shared: we have not yet set a conclusion When: we have not yet set a conclusion To whom: we have not yet set a conclusion Conditions: we have not yet set a conclusion Where to obtain: we have not yet set a conclusion How to obtain: we have not yet set a conclusion Comments:
public Pooya Derakhshan
Iran University of Medical Sciences., next to Milad Tower., Hemat Highway
Tehran Iran (Islamic Republic of) 1449614535 +98 21 8163 3685 Pooya_derakhshan@bums.ac.ir Iran University of Medical Sciences scientific Pooya Derakhshan
Iran University of Medical Sciences., next to Milad Tower., Hemat Highway
Tehran Iran (Islamic Republic of) 1449614535 +98 21 8163 3685 pooya_derakhshan@bums.ac.ir Iran University of Medical Sciences Iran (Islamic Republic of) All patient for knee arthroscopy surgery under general anesthesia 18 to 60 years old ASA 1-2 class 18 years 60 years Both history of sensitivity to drugs that used in study Opium addiction S83.5 Sprain of cruciate ligament of knee Treatment - Other Treatment - Other Treatment - Other Intervention group 1 : 100 mg oral Gabapentine, 1hour before surgery Intervention group 2: 1mg/kg oral Dextromethorphan 1hour before surgery Intervention group 3: 100 mg oral Gabapentine and 1mg/kg oral Dextromethorphan compound soluble in water, 1hour before surgery Pain rate. Timepoint: NRS scale at 0, 2, 4, 8, 12, and 24 hours. Method of measurement: Numeric Rating Scale ; Ramsay. Iran University of Medical Sciences Approved 2016-12-09 Ethics committee of Iran University of Medical Sciences Rasoul Akram Hospital ; Mansouri St ; Satarkhan St Tehran Tehran Iran (Islamic Republic of)