IRCT20190503043450N1 IRCT 2020-01-18 Zahedan University of Medical Sciences Comparison of the effect of erythropoietin and ozone on joint function in patients with knee osteoarthritis Comparison prolotherapy with erythropoietin and ozone with injections of sodium hyaluronate, chondroitin sulfate and ozone in reducing pain in patients with knee osteoarthritis 2019-05-22 anticipated 100 Complete https://irct.ir/trial/39251 interventional Randomization: Not randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive. 3 Knee osteoarthritis. Intervention 1: Intervention group 1: Erythropoietin injection twice with 3 weeks intervals with dose as 4000 International Units per milliliter made in Iran in Razavi pharmaceutical company in cooperation with Austria country, with 7 cc ozone 25 µg / ml in knee joint. Intervention 2: Intervention group 2: Injection of 3 cc mixture of sodium hyaluronate and chondroitin sulfate solution produced by Raha Pharmaceutical Company in collaboration with France country once with 7 cc ozone 25 µg / ml in knee joint. Yes - There is a plan to make this available What will be shared: Main outcome information When: 12 months after publishing results To whom: Researchers working in academia Conditions: To verify the results and prevent repetition in similar research Where to obtain: Library and website of Zahedan University of Medical Sciences How to obtain: Refer to the library and website of Zahedan University of Medical Sciences and have access to a maximum of one week Comments: