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IRCT20120915010841N18 IRCT 2019-05-17 Hamedan University of Medical Sciences Efficacy of intravenous Atropine in prevention of post spinal hypotension and bradycardia in cesarean section. Evaluation of Efficacy of intravenous Atropine in prevention of post spinal hypotension and bradycardia in cesarean section. 2019-05-15 anticipated 88 Complete https://irct.ir/trial/39401 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study , a randomized block design with four replications is used. we provide four paper sheets . We write two letters A and on two other sheets of letter B. We mix the papers together and put them in the drawer of the table.With each of the qualified patients, one of the papers is taken out randomly and will be assigned to one of the two Atropine 0.5 mg or 1 ml of normal saline groups, depending on whether the drawn sheet is either A or B. After the random drawn out of four sheets, all the papers will be returned to the drawer and again the above procedure will continue for the next four patients until it reaches the sample volume, Blinding description: In both groups A and B, medications will be prescribed two minutes before the extubation of the chip. In order to prevent the medication being detectable for patients and investigators, they are prepared and injected into syringes of the same size and shape and on the adhesives A and B by the anesthetist. Since drugs are prescribed and prescribed by an anesthetist, the clinician will not be aware of the type of prescribed medication that will measure and record the outcome of the study. 1-2 Spinal anesthesia in cesarean section. Intervention 1: Intervention group: 0.5 mg of atropine is injected intravenously after spinal anesthesia. Intervention 2: Control group: 1 ml of normal saline is injected intravenously immediately after spinal anesthesia. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Because the study is not finished yet.
public Nahid Manouchehrian
Fatemieh Hospital, Pasdaran Street
Hamadan Iran (Islamic Republic of) 6517789971 +98 81 3827 7012 manuchehriann@gmail.com Hamedan University of Medical Sciences scientific Nahid Manouchehrian
Pasdaran Street
Hamadan Iran (Islamic Republic of) 6517789971 +98 81 3827 7012 manuchehriann@gmail.com Hamedan University of Medical Sciences Iran (Islamic Republic of) Satisfaction to participate in the project Pregnant women aged 18 to 46 Pregnant women who underwent cesarean section under spinal anesthesia 18 years 40 years Female sensitivity to medications used Patients who have failed spinal anesthesia and undergo general anesthesia Lung disease, heart disease, asthma, fever, hypertension, preeclampsia and eclampsia, cardiac arrhythmia Multiple pregnancies HR resting more than 100 in minutes, Beta-blocker intake Z38.01 Single liveborn infant, delivered by cesarean Treatment - Drugs Treatment - Drugs Intervention group: 0.5 mg of atropine is injected intravenously after spinal anesthesia Control group: 1 ml of normal saline is injected intravenously immediately after spinal anesthesia. Hypotension. Timepoint: Every two minutes to 10 minutes, then every 5 minutes to 15 minutes, then every 10 minutes until the end of the surgery. Method of measurement: Non-invasive blood pressure. Bradycardia. Timepoint: Every two minutes to 10 minutes, then every 5 minutes to 15 minutes, then every 10 minutes until the end of the surgery. Method of measurement: Pulse Oximetry. Nausea & vomiting. Timepoint: after delivery. Method of measurement: Observation. Hamedan University of Medical Sciences Approved 2019-03-09 Ethics Committee of Hamadan university of Medical Science Fahmide Street Hamadan Hamadan Iran (Islamic Republic of)