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IRCT20190508043529N1 IRCT 2019-08-15 Shiraz University of Medical Sciences corneal crosslinking in keratoconus patients Continuous-light versus pulsed-light accelerated corneal crosslinking with ultraviolet-A and riboflavin in keratoconus patients 2019-06-21 anticipated 124 Complete https://irct.ir/trial/39485 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Based on the block-randomization methods with blocks of size 4, patients will be randomly assigned to both intervention groups, Blinding description: Participants, Statistician, and data collector will be kept blind. 2-3 Keratoconus. Intervention 1: Intervention group 1: (continuous-light accelerated CXL group); Accelerated CXL with continuous-light using 9 mW/cm2 for 10 minutes . Intervention 2: Intervention group 2: (pulsed-light accelerated CXL group); Accelerated CXL with pulsed on/off light using 9 mW/cm2 for 10 minutes. Yes - There is a plan to make this available What will be shared: Data can be achieved upon reasonable request sent to corresponding authors. When: Starting 2 years after publication To whom: Academic researchers Conditions: Data can be achieved upon reasonable request sent to corresponding authors. Where to obtain: Department of Ophthalmology, Shiraz University of medical sciences, Dr. Ramin Salouti: saloutir@hotmail.com How to obtain: Data can be achieved upon reasonable request sent to corresponding authors. Department of Ophthalmology, Shiraz University of medical sciences, Dr. Ramin Salouti: saloutir@hotmail.com Comments:
public Nasrin Masihpour
Zand street
Shiraz Iran (Islamic Republic of) 1234567890 +98 71 3629 1127 nasrin.masihpour@gmail.com Shiraz University of Medical Sciences scientific Nasrin Masihpour
Zand street
Shiraz Iran (Islamic Republic of) 1234567890 +98 71 3629 1127 nasrin.masihpour@gmail.com Shiraz University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Progressive keratoconus (Progression of the disease was considered as confirmed if the loss of corrected distance visual acuity (CDVA) was more than one line in 1 year, or when the topographic keratometry increased by >1.0 D in 6 months or >2.0 D in 12 months) The thinnest central corneal thickness (CCT) >400 µm 6 years 30 years Both Patients who wear contact lenses for one month prior to the initial evaluation and treatment Patients with immune system disorders Patients with corneal scar Patients with history of herpes simplex keratitis Patients who were pregnant or breastfeeding H18.6 Keratoconus Treatment - Surgery Treatment - Surgery Intervention group 1: (continuous-light accelerated CXL group); Accelerated CXL with continuous-light using 9 mW/cm2 for 10 minutes . Intervention group 2: (pulsed-light accelerated CXL group); Accelerated CXL with pulsed on/off light using 9 mW/cm2 for 10 minutes. Best corrected spectacle visual acuity (BSCVA). Timepoint: 6 months after intervention. Method of measurement: E-chart. Keratometric indices. Timepoint: 6 months after intervention. Method of measurement: Pentacam. Biomechanical parameters. Timepoint: 6 months after intervention. Method of measurement: Corvis. Shiraz University of Medical Sciences Approved 2019-04-09 Ethics committee of Shiraz University of Medical Sciences Zand street Shiraz Fars Iran (Islamic Republic of)