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IRCT20170101031697N2 IRCT 2019-06-25 Bandare-abbas University of Medical Sciences The efficacy of Ondansetron and Granisetron in preventing of post Laparascopic Cholesystectomy nausea and vomiting The efficacy of Ondansetron and Granisetron in preventing of post Laparascopic Cholesystectomy nausea and vomiting (PONV) 2016-03-20 anticipated 90 Complete https://irct.ir/trial/39590 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: After identifying the patients, patients were randomly assigned to the study groups. Randomization was carried out in a sub-unit using statistical software, Blinding description: The pump syringes were prepared by an expert in the anesthetic room and the assistant did not know its content. 3 nausea and vomiting. Intervention 1: First intervention group: Patients in this group received 2 mg of Granisetron (in a total volume of 10 ml), 5 minutes before induction of anesthesia. Intervention 2: Second intervention group: Patients in this group received 4 mg of Ondansetron (in a total volume of 10 ml), 5 minutes before induction of anesthesia. Yes - There is a plan to make this available What will be shared: SPSS file When: 5/17/2019 To whom: Researchers and referees Conditions: Obtaining a written permit and mentioning the name in the sources Where to obtain: Dr. Saeed Kashani Sdkashani486@gmail.com How to obtain: Email your request. Comments:
public Said Kashani
Department of Anesthesiology , Shahid Mohammadi Hospital, Jomhouri Islami St, Imam Khomeini Blvd
Bandar Abbas Iran (Islamic Republic of) 7919915519 +98 76 3334 5009 Sdkashani486@gmail.com Bandare-abbas University of Medical Sciences scientific Said Kashani
Department of Anesthesiology , Shahid Mohammadi Hospital, Jomhouri Islami St, Imam Khomeini Blvd
Bandar Abbas Iran (Islamic Republic of) 7919915519 +98 76 3334 5009 Sdkashani486@gmail.com Bandare-abbas University of Medical Sciences Iran (Islamic Republic of) Patients with ASA grade one Patients with ASA grade two Patient were referred for laparoscopic cholecystectomy 18 years 60 years Both Febrile illness History of infection Pulmonary disease Allergy to Endonestrone Allergy to Granisetron History of seizure History of vascular contraction Intracranial pressure History of drug abuse Patients who do not have proper collaboration during the study History of digestive disease Emergency patients Patients with a history of motion sickness (PTSD) or motion sickness (PONV) have a history of nausea and vomiting Surgery Patients with history of nausea and vomiting during previous surgery Patients who received anti-nausea and vomiting before surgery Patients with hypothermia (below 36 ° C) Pregnancy Inability to perceive VAS criteria for pain The patient's consent for participation in the study Weight more than 120kg Weight less than 50kg R11 Nausea and vomiting Treatment - Drugs Treatment - Drugs First intervention group: Patients in this group received 2 mg of Granisetron (in a total volume of 10 ml), 5 minutes before induction of anesthesia. Second intervention group: Patients in this group received 4 mg of Ondansetron (in a total volume of 10 ml), 5 minutes before induction of anesthesia. Nausea and vomiting. Timepoint: Patients were monitored for nausea and vomiting during recovery and after recovery for 24 hours during the hours (2-4-6-12-24). Method of measurement: According to Clinical Obstetrician Anesthesiologist. Bandare-abbas University of Medical Sciences Approved 2017-09-20 Ethics Committee of Bandar Abbas University of Medical Sciences Ethics Committee of Bandar Abbas University of Medical Sciences,Research Deputy Building, Shahid Mohammadi Hospital, Jomhoori Islami Blvd. Bandar Abbas Hormozgan Iran (Islamic Republic of)