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IRCT201103183836N1 IRCT 2011-08-13 Jundishapour Ahvaz Uuniversity of Medical Science Sequential Therapy versus Quadruple Therapy for H.pylori Eradication in Iran To compare the efficacy of quadruple and sequential therapy in eradication of H.Pylori: in a Sequential Therapy versus Quadruple Therapy for H.pylori Eradication in Iran 2011-12-02 anticipated 300 Complete https://irct.ir/trial/3963 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 1-2 Condition 1: Peptic ulcer. Condition 2: Gastritis. Intervention 1: Group I (n=150) will receive quadruple therapy (20 mg omperazole bid, 240 mg bismuth subcitrate bid, 1000 mg tetracycline bid and 500 mg metronidazole bid) for 14 days. Intervention 2: Group II (n=150) will receive sequential therapy (20 mg omp bid, 1000 mg amoxicillin bid for 5 days, follow by 20 mg omperazole bid, 500mg metronidazole bid, 500mg clarithromycin for the other 5 days).
public Abdolrahim Masjedizadeh
Azadgan Street-Imam Hospital
Ahvaz Iran (Islamic Republic of) 6193673166 +98 61 1337 6922 masjedi_r@ajums.ac.ir Jondishapou Ahvaz University of Medical Sciences scientific Eskandar Hajiani
Golstan, Univercity City
Ahvaz Iran (Islamic Republic of) 6193673166 +98 61 1222 2922 ehajiani@gmail.com Jundishapour Ahvaz Uuniversity of Medical Science Iran (Islamic Republic of) Inclusion: Patients older than 14 years of age with dyspepsia, gastrointestinal bleeding, history of post prandial fullness and vomiting, undertake endoscopy.Two biopsies of the antrum and gastric body will perform. Those patients who have a positive rapid urease test or histological evidence for H. pylori in the gastric mucosa will enroll. Exclusion:Patients with severe comorbidity, such as cirrhosis, kidney failure, severe heart disease, pregnancy, lactation and evidence of malignancy, a previous history of eradication of H. pylori, a history of NSAID use, alcohol consumption and H2 blocker or PPI in the past two weeks or who haVE receive antibiotics and bismuth subcitrate in the last month will be excluded. 14 years 60 years Both K25-K26 K29 Gastric ulcer -Duodenal ulcer - erosion (acute) of stomach -erosion (acute) of duodenum Chronic gastritis, unspecified , Acute (erosive) gastritis with haemorrhage Treatment - Drugs Treatment - Drugs Group I (n=150) will receive quadruple therapy (20 mg omperazole bid, 240 mg bismuth subcitrate bid, 1000 mg tetracycline bid and 500 mg metronidazole bid) for 14 days Group II (n=150) will receive sequential therapy (20 mg omp bid, 1000 mg amoxicillin bid for 5 days, follow by 20 mg omperazole bid, 500mg metronidazole bid, 500mg clarithromycin for the other 5 days) Eeradication helicobacter pylori. Timepoint: Four weeks. Method of measurement: Urea breath test. Side effect. Timepoint: Three days. Method of measurement: Good, intermediate and poor assessed by physician. Jundishapour Ahvaz Uuniversity of Medical Science Approved 2011-06-20 Jundishapour Ahvaz University of Medical Science Golstan highway Ahvaz Iran (Islamic Republic of)