IRCT201108073836N2 IRCT 2011-08-23 Jundishapour Ahvaz University of Medical Sciences Efficacy of early Helicobacter Pylori eradication versus continuous pantoprazol Infusion in prevention of rebleeding in peptic ulcer patients Efficacy of early Helicobacter Pylori eradication versus continuous pantoprazol infusion in prevention of rebleeding in peptic ulcer patients 2011-12-14 anticipated 102 Complete https://irct.ir/trial/3964 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. 3 Peptic ulcer-GI bleeding. Intervention 1: Group H (control group) will be treated by Omeprazole 20mg two times a day(BID), subcytrate bismuth 240mg BID, metronidazole 500mg BID and tetracycline 1000mg BID for 14 days. Intervention 2: The group P (case) will receive pantoprazol 80 mg intravenously, stat and then 8mg/h infusion for 72 hours.

public Abdolrahim Masjedizadeh

Azadgan Street-Imam hospital-Gastroentrology Ward

Ahvaz Iran (Islamic Republic of) 6193673166 +98 61 1222 2922 rmasjedi@hotmail.com Imam Hospital scientific Eskandar Hajiani

Azadgan Street, Imam hospital, Gasterology ward

Ahvaz Iran (Islamic Republic of) 6193673166 +98 61 1222 2922 ehajiani@gmail.com Imam Hospital Iran (Islamic Republic of) The bleeding peptic ulcer patients with age ≥ 16 y old who have stigmata of recent bleeding like active spurting ( Forrest IA), non bleeding visible vessel ( Forrest IIA), oozing or adherent clot with visible vessel ( Forrest IA, IB, IIA) will be included in study. The exclusion criteria are: esophageal varicose, liver cirrhosis, malignancy, concomitant morbidity, cardiac pacemaker, NSAID consumption, current therapy with anti coagulant, antibiotic or PPI and multiple ulcers. 16 years 89 years Both k25-k26 Gastric ulcer -Duodenal ulcer -Acute with haemorrhage Treatment - Drugs Treatment - Drugs Group H (control group) will be treated by Omeprazole 20mg two times a day(BID), subcytrate bismuth 240mg BID, metronidazole 500mg BID and tetracycline 1000mg BID for 14 days The group P (case) will receive pantoprazol 80 mg intravenously, stat and then 8mg/h infusion for 72 hours Rebleeding. Timepoint: One week. Method of measurement: Hematemesis, Repeating melena, >2gr/dl Decrease in Hb level, Pulse rate > 90/min or sudden drop in blood pressure. Surgery. Timepoint: One Week. Method of measurement: Number. Transfustion. Timepoint: One week. Method of measurement: Number. Mortality. Timepoint: One week. Method of measurement: Number. Duration of admission. Timepoint: One week. Method of measurement: Day. Rebleeding. Timepoint: 0ne month. Method of measurement: Hematemesis, Repeating melena, >2gr/dl Decrease in Hb level, Pulse rate > 90/min or sudden drop in blood pressure. Surgery. Timepoint: One month. Method of measurement: Number. Transfustion. Timepoint: One month. Method of measurement: Number. Mortality. Timepoint: One month. Method of measurement: Number. Duration Admission. Timepoint: One month. Method of measurement: Day. Jundishapour Ahvaz University of Medical Sciences Approved 2010-08-20 Jundishapour Ahvaz University of Medical Sciences Golestan-University city-Ethnical and research committee of Jundishapour University of Medical Sciences Ahvaz Iran (Islamic Republic of)