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IRCT201403173862N10 IRCT 2014-04-15 Research Council of Mashhad University of Medical Sciences Comparison the therapeutic effects of liposomal tranexamic acid form and conventional form of Hydroquinone on melasma patients Comparison the therapeutic effects of liposomal tranexamic acid and Hydroquinone on melasma patients 2011-08-03 anticipated 30 Complete https://irct.ir/trial/4007 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: This study is performed as double blind, as the patients and the physicians of disease severity are not alert about which therapeutic form will be used in each side of the face. 2 Melasma. Intervention 1: Control group: hidroqinone cream 2%, one time/day on the lesion of one side of face. Intervention 2: Intervention group: liposomal tranexamic acid cream 1 time/day on the lesion of one side of face.
public Asma Jabari
Ghaem hospital, Ahmad Abad street
Mashhad Iran (Islamic Republic of) +98 51 1864 2637 asma_v_jabari@yahoo.com Mashhad University of Medical Sciences scientific Dr Mahnaz banihashemi, Dr Mahmoud Reza Jafari, Dr Naghmeh Zabolinejad
Department of dermatology, Ghaem hospital, Ahmad Abad street
Mashhad Iran (Islamic Republic of) +98 51 1801 2861 banihashemim@mums.ac.ir, jafarimr@mums.ac.ir, zabolinejadng@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: clinically diagnosed melisma patients, age more than 18 years old. Exclusion criteria: pregnancy and breast feeding, simultaneous hormonal disease, drug use including anti barbiturate drugs, recent hormonal and corticosteroids treatments, patients who treated by bleaching therapy on the last four months, patients underwent laser during the last six month, patients who don’t refer on follow up periods, any side effects which canceled the treatment. 18 years 70 years Both L81.1 Melasma Treatment - Drugs Treatment - Drugs Control group: hidroqinone cream 2%, one time/day on the lesion of one side of face Intervention group: liposomal tranexamic acid cream 1 time/day on the lesion of one side of face Improvement of pigmentation. Timepoint: Monthly untill the end of 12 weeks. Method of measurement: Melasma Area and Severity Index. Melasma severity. Timepoint: Comparison melasma severity in baseline and terminal of 3 months treatment course. Method of measurement: Melasma Area and Severity Index. Research Council of Mashhad University of Medical Sciences Approved 2010-09-23 Ethics Committee of Mashhad University of Medical Sciences Central Building of Mashhad University of Medical Sciences (Ghorshi), daneshgah 16, Daneshgah Street Mashhad Iran (Islamic Republic of)