IRCT20161010030246N4 IRCT 2019-09-08 Shiraz University of Medical Sciences Comparison effect of intravenous sodium bicarbonate and sodium chloride combination versus intravenous sodium chloride hydration in reducing of amphotericin B-induced nephrotoxicity Comparison effect of intravenous sodium bicarbonate and sodium chloride combination versus intravenous sodium chloride hydration in reducing of amphotericin B-induced nephrotoxicity 2018-10-23 anticipated 40 Complete https://irct.ir/trial/40103 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: Clinical trials are simple randomized, one-blind, and placebo-free that the patient did not know. The possibility of double-blind due to the lack of a clean room and the required facilities as well as the different appearance of sodium bicarbonate and sodium chloride Did not have. unit of randomization is individual a randomization method using a random number table, Blinding description: This study was conducted in a single blind setting that That the participants are blind in this study. It is impossible to conduct this clinical trial as double-blinded due to the lack of a clean room and the required facilities as well as the appearance of the sodium bicarbonate and sodium chloride looks different. 3 Nephrotoxicity. Intervention 1: Intervention group: Includes 20 patients who received 500 ml of normal saline before injection of amphotericin and 1.5 vial sodium bicarbonate vial in 500 cc dextrose water, equivalent to the normal saline mEq 159, sodium bicarbonate is given to patients. Intervention 2: Control group: Includes 20 patients with 1000 ml normal saline 0.9% equivalent to 159 mEq in two divided doses (500 ml) before and after infusion of amphotericin is given to patients. No - There is not a plan to make this available Justification or reason for not sharing IPD is No more information