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IRCT20190615043899N1 IRCT 2019-07-16 Boushehr University of Medical Sciences Comparison of preemptive analgesic effect of Naproxen, Celecoxib and Acetaminophen codeine on pain control after mandibular third molar surgery Comparison of preemptive analgesic effect of Naproxen, Celecoxib and Acetaminophen codeine on pain control after mandibular third molar surgery in patients to dentistry clinic of bushehr university of medical sciences 2019-02-20 anticipated 78 Complete https://irct.ir/trial/40314 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients are divided into three groups of 24 patients using randomized block method. According to random block allocation method, first, the volume of each block is determined, in this study, 12 blocks of 6 blocks were determined. After the block list was prepared, a number was allocated to each block. Then, random numbers were chosen between 1 and 12, and the random allocation list was selected according to the order of random numbers, Blinding description: The way of blinding was this: the drugs were embedded in insulating glasses of light and temperature and encoded under sterile gamma rays under laboratory conditions. The sample code was revealed after the study was completed and the results were revealed. Delivery of the drug to the patient and follow up of the patient's condition by someone other than the surgeon. The method of administration of the drug on the label of the drug was determined to be patient; who took the drug for three days according to the instructions, ie, naproxen 250 mg every 6 hours, celecoxib 100 mg every 12 hours and acetaminophen 325 mg every 6 hours. 2-3 Control of pain after third molar surgery. Intervention 1: Control group: In this study, acetaminophen codein was used as a standard dose (control) to evaluate the efficacy of other drugs; So, half an hour before, surgery was given to a group of acetaminophen 325 mg. Intervention 2: Intervention group: Half an hour before surgery, naproxen 250 mg (Pars Dara Company) was givenby this group. Intervention 3: Intervention group: Half an hour before surgery, another group took100 mg celecoxib (Darupakhsh, Tehran). Yes - There is a plan to make this available What will be shared: Only part of the data, such as the key outcome information or the like, can share When: Start the access period 6 months after printing the results To whom: Only for researchers working in academic and scientific institutions Conditions: Not allowed Where to obtain: Dr seyed mehdi hosseini pmn.hsn30067@gmail.com How to obtain: A week after the request Comments:
public Seyed Mehdi Hosseini
No. 1, Line 332, Deadlock 4, Imam Blvd
Bushehr Iran (Islamic Republic of) 75167-96479 +98 77 3344 8061 pmn.hsn30067@gmail.com Boushehr University of Medical Sciences scientific Seyed Mehdi Hosseini
No. 1, Line 332, Deadlock 4, Imam Blvd
Bushehr Iran (Islamic Republic of) 75167-96479 +7 733448061 pmn.hsn30067@gmail.com Boushehr University of Medical Sciences Iran (Islamic Republic of) Patient OPG to confirm that the hardness of the lower third molar is the same. Patient-patient pain rating History of systemic diseases Patient should not have a history of hypersensitivity to steroid drugs Patient in the range of 18 to 60 years old Avoid taking an hour before taking analgesic A person can read and understand the checklist The patient does not take analgesic because of chronic pain 18 years 40 years Both There is an infection of the postoperative dry socket Diabetic patients Systemic drug interactions with the three drugs in this study Use of psychological drugs The presence of rotting teeth or needing treatment in the mouth Lack of cooperation for future referrals Systemic disease People who had started treating the wound of the gastrointestinal tract for 30 days before surgery Used analgesics or another drug for 24 hours before surgery History of narcotic or analgesic addiction Patients who were pregnant or Breastfeeding Known sensitivity to anti-inflammatory drugs, non-steroidal anti-inflammatory drugs ordinary or cyclooxygenase-2 inhibitors XIX Injury, poisoning and certain other consequences of external causes Treatment - Drugs Treatment - Drugs Treatment - Drugs Control group: In this study, acetaminophen codein was used as a standard dose (control) to evaluate the efficacy of other drugs; So, half an hour before, surgery was given to a group of acetaminophen 325 mg. Intervention group: Half an hour before surgery, naproxen 250 mg (Pars Dara Company) was givenby this group. Intervention group: Half an hour before surgery, another group took100 mg celecoxib (Darupakhsh, Tehran). The severity of pain. Timepoint: The severity of pain was the patient who was recorded in the questionnaire during the prescribed hours (7 days and 72, 48, 24, 12, 8, 4). Method of measurement: The severity of pain was as follows: the patient, based on her sense of pain, determined a number between 10-1 according to the definition of the pain states based on the degree of discomfort / pain. The number 1 indicates that the patient feels good and does not feel pain, and the number 10 indicates a painful pain, to the extent that the patient leaves all his work and feels the need for rest. Boushehr University of Medical Sciences Approved 2019-02-18 Ethics Committee of Bushehr University of Medical Sciences No. 1, Line 332, Deadlock 4, Imam Blvd Bushehr Boushehr Iran (Islamic Republic of)