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IRCT20190622043979N1 IRCT 2019-06-26 Qazvin University of Medical Sciences Comparison of treatment with Repetitive Trans cranial Magnetic Stimulation with medication, with medication alone in obsessive-compulsive disordered Comparison of treatment with Repetitive Trans cranial Magnetic Stimulation with medication, with medication alone in obsessive-compulsive disordered resistance to medication 2019-07-22 anticipated 30 Complete https://irct.ir/trial/40327 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The randomization is done using block method. Unit of randomization is individual. Randomization is done using a table of random numbers and to generate random sequences as online, computer is used. For concealing treatment allocation, the list of treatments are placed in the enclosed and numbered (to maintain order of sequences) envelopes , Blinding description: This study is triple blind, and each patients receive a code, whether RTMS or SHAM is done by one of the nurses. Main contributors to the project, and the patients and the one who finally analyzes the results, all of them are not aware of patients assignment to groups. 3 Obsessive compulsive disorder resistance to drug therapy. Intervention 1: Intervention group: Therapeutic drug for 3 weeks and 5 times per week with a frequency of 1 Hz for 20 minutes (1200 pulses / day). Intervention 2: Control group: Therapeutic drug plus SHAM (placement of the device without magnetic stimulation on the head). No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information
public Ghazal Jahan Bakhsh
Rah ahan street, Qazvin
Qazvin Iran (Islamic Republic of) 3419759811 +98 28 3356 5712 dralihsj52@gmail.com Qazvin University of Medical Sciences scientific Alireza Haj Seyed Javadi
Rah ahan street, Qazvin
Qazvin Iran (Islamic Republic of) 3419759811 +98 28 3356 5712 dralihsj52@gmail.com Qazvin University of Medical Sciences Iran (Islamic Republic of) Age 18-60 A previous history of OCD for at least one year, treated with the first two Obsessive drugs approved by the FDA, has not been improved and is right-handed. In the YBOCS questionnaire, the score was more than or equal to 16, and in the Beck questionnaire the score was not higher than 17. 18 years 60 years Both Accompanied with other psychiatric disorders History of seizure or epileptic seizures Beck questionnaire score above 17 Pregnancy Substance abuse based on biographie History of severe head trauma or severe neurological complications Metal implant or pace maker F42 Obsessive-compulsive disorder Treatment - Drugs Treatment - Drugs Intervention group: Therapeutic drug for 3 weeks and 5 times per week with a frequency of 1 Hz for 20 minutes (1200 pulses / day) Control group: Therapeutic drug plus SHAM (placement of the device without magnetic stimulation on the head) Improvement. Timepoint: Obsessive compulsive disorder will be assessed in both groups of A and B after 3 weeks. Method of measurement: At the end of the study, the mean scores of the questionnaire, as well as the clinical observations and clinical assessments of the questioner, were compared in both groups compared to the beginning of the study and the other group in order to determine the effectiveness of each regimen independently and in comparison with others as well as the rate of remission. Qazvin University of Medical Sciences Approved 2019-02-20 Ethics Committee of Qazvin University of Medical Sciences Shahid Bahonar Blvd., Qazvin Qazvin Qazvin Iran (Islamic Republic of)