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IRCT20171030037093N15 IRCT 2019-07-11 Shahre-kord University of Medical Sciences Comparison of immunotherapy with aeroallergens and drug treatment in patients with allergic rhinitis Comparison of immunotherapy with aeroallergens and drug treatment in patients with allergic rhinitis 2019-07-23 anticipated 120 Complete https://irct.ir/trial/40400 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In order to randomize the study, simple randomization with individual unit was used, so that patients randomly selected one of the cards containing the code A or B so they entered one of the two treatment groups. 3 Allergic rhinitis. Intervention 1: Intervention group: Patients received the usual drug treatment, including inhaled glucocorticoids (Fluticasone) and antihistamines once a day for one month. Intervention 2: Intervention group: Patients who had a positive prick test underwent immunotherapy with allergen extract with three vials diluted 1: 10,000 pg per week for 10 sessions, 1: 1000 pg every other week for 10 sessions and then dilution of 1: 100 pg every month for 2 years. Yes - There is a plan to make this available What will be shared: Information on the main outcome can be shared. When: Start the access period 4 months after publishing the results To whom: Researchers working in academia Conditions: Use data to complete clinical trial studies Where to obtain: Kashani Hospital in Shahrekord, zamani.m@skums.ac.ir How to obtain: After the investigation of resercher request and presentation of required documents will be accessible. Comments:
public Mohammad Ali Zamani
Shahrekord University of Medical Sciences, Building No. 2, University headquarters, Ayatollah Kashani Blvd
Shahrekord Iran (Islamic Republic of) 8815713471 +98 38 3334 2414 zamani.m@skums.ac.ir Shahre-kord University of Medical Sciences scientific Mohammad Ali Zamani
Shahrekord University of Medical Sciences, Building No. 2, University headquarters, Ayatollah Kashani Blvd
Shahrekord Iran (Islamic Republic of) 8815713471 +98 38 3227 4004 zamani.m@skums.ac.ir Shahre-kord University of Medical Sciences Iran (Islamic Republic of) Age 10 and over 10 years Age less than 50 years Lack of advanced and severe asthma Negative pregnancy test for women Lack of autoimmune disease Lack of immunodeficiency disease Lack of malignancy 10 years 50 years Both Patient lack of cooperation Continuous use of immunosuppressive drugs Continuous use of antihistamines Taking beta-blocker medications History of allergy to each of the treatment groups J30.9 Allergic rhinitis, unspecified Treatment - Drugs Treatment - Other Intervention group: Patients received the usual drug treatment, including inhaled glucocorticoids (Fluticasone) and antihistamines once a day for one month. Intervention group: Patients who had a positive prick test underwent immunotherapy with allergen extract with three vials diluted 1: 10,000 pg per week for 10 sessions, 1: 1000 pg every other week for 10 sessions and then dilution of 1: 100 pg every month for 2 years. Sneeze. Timepoint: Before intervention, 2 years after intervention. Method of measurement: Checklist containing clinical symptoms. Cough. Timepoint: Before intervention, 2 years after intervention. Method of measurement: Checklist containing clinical symptoms. Rhinorrhea. Timepoint: Before intervention, 2 years after intervention. Method of measurement: Checklist containing clinical symptoms. Itchy eyes. Timepoint: Before intervention, 2 years after intervention. Method of measurement: Checklist containing clinical symptoms. Itchy throat. Timepoint: Before intervention, 2 years after intervention. Method of measurement: Checklist containing clinical symptoms. Post nasal discharge. Timepoint: Before intervention, 2 years after intervention. Method of measurement: Checklist containing clinical symptoms. Nasal congestion. Timepoint: Before intervention, 2 years after intervention. Method of measurement: Checklist containing clinical symptoms. Shahre-kord University of Medical Sciences Approved 2018-07-22 Ethics Committee of Shahrekord University of Medical Sciences Vice chancellor for research, Building No. 2, University headquarters, Ayatollah Kashani Blvd Shahrekord Chahar-Mahal-va-Bakhtiari Iran (Islamic Republic of)