IRCT20190513043578N1 IRCT 2019-07-30 Tabriz University of Medical Sciences Surgical management of nasal septal perforation by mucosal flap rotation and amniotic membrane graft Surgical management of nasal septal perforation by mucosal flap rotation and amniotic membrane graft 2019-07-23 anticipated 12 Complete https://irct.ir/trial/40453 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. N/A nasal septum perforation. Intervention group: After general anesthesia and oral intubation, lidocaine 2% with epinephrine 1 100,000 will be injected in septal area . Then, using the hemitransfixion incision, the mocoperichondrial flap will be raised and the edges of the perforation will be cut off with a blade. Before elevating the flap, an aluminum suture envelope will be placed to support the mucoperichondrial flap. Then on the opposite side, the cut from the posterior and lower parts of the septum will begin to elevate mucusal flap, and will continue to the anterior and upper to reach the anterior margin of the perforation. This flap is based on the posterior nasal artery, which is a branch of the sphenopalatine artery.In some cases, releasing the posterior side of the flap will increase the radius of rotation. This flap will cover the edges of the perforation. Amniotic membrane will be provided from the cesarean section of the volunteer patients . This membrane is first completely washed with normal saline and stored in normal saline and one gram cephalexin in the refrigerator at 4 ° C. The amniotic membrane in five layers as an Interpositional graft will be placed in the mucoperichonrial pocket .sutures will be used to fix the membrane and prevent the formation of hematoma. the nose packed for three days.. No - There is not a plan to make this available Justification or reason for not sharing IPD is No more information