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IRCT201207223915N7 IRCT 2012-07-25 Research VICE chancellor of Tabriz University of Medical Sciences comparing different drugs in prevention of post-tympanoplsty nausea and vomiting Comparison of different doses of granisetron plus dexamethasone versus ondansetron plus dexamethasone in prevention of postoperative nausea and vomiting in patients undergoing tympanoplasty 2011-03-06 anticipated 160 Complete https://irct.ir/trial/4059 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. 2-3 post tympanoplasty nausea and vomiting. Intervention 1: dexamethasone 8 mg IV immediately after intubation for all patients plus granisetron 0.1 mg 15 minutes before extubation in group A. Intervention 2: granisetron 0.3 mg 15 minutes before extubation plus post intubation dexamethasone in group B. Intervention 3: Ondansetron 4mg 15 minutes before extubation in addition to post intubation dexamethasone in group C.
public Ali Perovifar
Operation room. Immamm Reza Hospital
Tabriz Iran (Islamic Republic of) +98 41 1334 7054 peirovifara@yahoo.com Tabriz University of Medical Sciences scientific Ali Peirovifar
Operation room. Immam Reza Hospital
Tabriz Iran (Islamic Republic of) +98 41 1334 7054 peirovifara@yahoo.com Tabriz University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: patients that are candidate for tympanoplasty with ASA class I or II and age 15-60 year. Exclusion criteria: gastrointestinal diseases, history of treatment with anti emetics or drugs with anti emesis effects at 24 hours before surgery, BMI more than 36.5, pregnant or lactating mothers, opiate abuse, sensitivity reaction to studied drugs. 15 years 60 years Both Y83.8 Other surgical procedures Treatment - Drugs Treatment - Drugs Treatment - Drugs dexamethasone 8 mg IV immediately after intubation for all patients plus granisetron 0.1 mg 15 minutes before extubation in group A granisetron 0.3 mg 15 minutes before extubation plus post intubation dexamethasone in group B Ondansetron 4mg 15 minutes before extubation in addition to post intubation dexamethasone in group C Post operative nausea and vomiting. Timepoint: every 0-2 hours till 24 hours. Method of measurement: clinical monitoring. Need for anti emetic drugs. Timepoint: every 0-2 hours till 24 hours. Method of measurement: Bellville score. Research VICE chancellor of Tabriz University of Medical Sciences Approved 2011-02-28 Ethic Committee of Tabriz University of Medical Sciences Golgasht Street. Tabriz University of Medical Sciences Tabriz Iran (Islamic Republic of)