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IRCT20190708044155N1 IRCT 2019-08-25 Esfahan University of Medical Sciences The effect of Dexmedetomidine، Ondansetrone، Pethidine on tremor after abdominal surgery The prophylactic effect of intravenous injection of Dexmedetomidine، Ondansetrone، Pethidine on tremor after abdominal surgery under the general anesthesia and comparisone with control group 2019-06-30 anticipated 128 Complete https://irct.ir/trial/40687 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: Patients are randomaly assigned to intervention and control groups with using the Random Allocation computer software, Blinding description: The drugs and placebo are prepared in one form and in the form of a volume in the syringe by the researcher and the hemodynamic changes created are monitored and recorded. Therefore, the participant and the clinical caregiver and evaluatorl and data analyser analyst do not understand the type of drug and after analyzing the codes by the researcher Decoded. 3 Teremor rate after surgery. Intervention 1: Intervention 1: In group D 0.5mg / kg dexmedetomidine - injected intravenously 1 time after the last wound is closed. Intervention 2: Intervention group 2: In group P 0.5mg / kg pethidine - injected intravenously 1 time after the last wound is closed. Intervention 3: Intervention group 3 in group O One tenth mg / kg ondansetron -injected intravenously 1 time after the last wound is closed. Intervention 4: In control group 1: In group N distilled water in syringe Similar volumes are also generated. All cases are volumeized 1 time and are injected intravenously 1 time after the last wound is closed. Yes - There is a plan to make this available What will be shared: Information about the main outcome is published. When: 3 months after printing the results To whom: Researchers working in academic and scientific institutions Conditions: For information on continuing research Where to obtain: mahsaheydari.mahsa@gmail.com 00989370272404 Mahsa Heidari-Isfahan University of Medical Sciences behzad_nazem@md.mui.ac.ir 00989162907797 Dr. Behzad Nazem Raaya-Al-Zahra Hospital How to obtain: Email your request. Comments:
public Mahsa Heydari
Shahid Keshvari Highway - Sofia Boulevard
Isfahan Iran (Islamic Republic of) 8174675731 +98 31 3620 2020 mahsaheydari.mahsa@gmail.com Esfahan University of Medical Sciences scientific Mahsa Heydari
Shahid Keshvari Highway - Sofia Boulevard
Isfahan Iran (Islamic Republic of) 8174675731 +98 31 3620 2020 mahsaheydari.mahsa@gmail.com Esfahan University of Medical Sciences Iran (Islamic Republic of) Men and women with ASA 1 and 2 Candidate for abdominal surgery under general anesthesia 18 to 60 years old 18 years 60 years Both History of Vasoactive Drugs, Opioids, TCA, MAOI Nerve and muscle disease Thyroid disease Fever Pregnancy Obesity BMI> 27 Cardiovascular, Respiratory, Endocrine, Neurological diseases Sensitivity to Pethidine, Ondansetrone, Ketamine R25.1 Tremor, unspecified Prevention Prevention Prevention Prevention Intervention 1: In group D 0.5mg / kg dexmedetomidine - injected intravenously 1 time after the last wound is closed Intervention group 2: In group P 0.5mg / kg pethidine - injected intravenously 1 time after the last wound is closed Intervention group 3 in group O One tenth mg / kg ondansetron -injected intravenously 1 time after the last wound is closed In control group 1: In group N distilled water in syringe Similar volumes are also generated. All cases are volumeized 1 time and are injected intravenously 1 time after the last wound is closed Tremor rate after surgery. Timepoint: For the first 15 minutes continuously and then every 15 minutes to 1 hour. Method of measurement: Crassly and Mahajan. Esfahan University of Medical Sciences Approved 2019-06-30 Ethics committee of Isfahan University of Medical Sciences Hezar jarib street Isfahan Isfehan Iran (Islamic Republic of)