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IRCT20140415017288N6 IRCT 2019-07-22 Islamic Azad University Effect of training and Garlic on Blood Pressure The effect of eight weeks aerobic training with garlic supplements on inflammatory and cardiovascular factors in postmenopausal women with high blood pressure and obesity 2019-08-06 anticipated 36 Complete https://irct.ir/trial/40719 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Health service research, Randomization description: In this research, subjects are selected Simple randomization by random allocation rule. After determining the sample size, they will be equally divided into four groups (Control, Water; Control, Garlic; Control, Training; Garlic, Training), Blinding description: The Control- Garlic and Garlic +Training patients receive Momordica charantia, two capsules orally of 500 mg twice daily before breakfast and dinner for 8 weeks. Control-Water and Control-Training groups receive placebo in the same pharmacological presentation. Starch is used as placebo. N/A Hypertensive diseases. Intervention 1: Control group: : in this group we have not any intervention during 6 weeks, and will consider this group as placebo. Intervention 2: Intervention group: Training group (in this group for 8 week, three session/weeks, the training start with 10 min warming and then 30 min 55% reserved heart rate, increase to the training time up 55 min until the end of intervention with 65% of the reserved heart rate). Intervention 3: Intervention group: Garlic group (in this group eat 1000 mg of Garlic for eight weeks Twice a day before breakfast and dinner). Intervention 4: Intervention group: Garlic - Training group (In this group the Simultaneous intervention, Garlic and training, will treat with the same protocol that describe at the previous part). Yes - There is a plan to make this available What will be shared: The report is submitted to the research department of the university. Also published as a paper. When: Since 2020 To whom: All researchers Conditions: Citing references Where to obtain: Scientific bases and Ayatollah Amoli Branch, Islamic Azad University, amol, Iran How to obtain: Maximum one week Comments:
public Ahmad Abdi
Ayatollah Amoli Branch, Islamic Azad University
Amol Iran (Islamic Republic of) 678 +98 11 4321 7126 a.abdi@iauamol.ac.ir Islamic Azad University scientific Alireza Barari
Ayatollah Amoli Branch, Islamic Azad University
Amol Iran (Islamic Republic of) 678 +1 143217126 alireza54.barari@gmail.com Islamic Azad University Iran (Islamic Republic of) Confirmation of blood pressure by the doctor Lack of other underlying illnesses Not attending a regular exercise program in the past six months Permission to participate in the exercise program with the opinion of a specialist physician Satisfaction to participate in the study Have at least 50 years of age 50 years 65 years Female Use supplement and practice Diagnosis of other underlying illnesses during protocol implementation Change in drug intake Risk of exercise or supplementation I10 Essential (primary) hypertension Placebo Treatment - Other Treatment - Other Treatment - Other Control group: : in this group we have not any intervention during 6 weeks, and will consider this group as placebo. Intervention group: Training group (in this group for 8 week, three session/weeks, the training start with 10 min warming and then 30 min 55% reserved heart rate, increase to the training time up 55 min until the end of intervention with 65% of the reserved heart rate). Intervention group: Garlic group (in this group eat 1000 mg of Garlic for eight weeks Twice a day before breakfast and dinner). Intervention group: Garlic - Training group (In this group the Simultaneous intervention, Garlic and training, will treat with the same protocol that describe at the previous part) Effect of aerobic training and Garlic on Lipocalin-2. Timepoint: Before and after the protocol. Method of measurement: Biochemical and laboratory methods. Effect of aerobic training and Garlic on IL-1β. Timepoint: Before and after the protocol. Method of measurement: Biochemical and laboratory methods. Effect of aerobic training and Garlic on MMP-3. Timepoint: Before and after the protocol. Method of measurement: Biochemical and laboratory methods. Effect of aerobic training and Garlic on MMP-9. Timepoint: Before and after the protocol. Method of measurement: Biochemical and laboratory methods. Effect of aerobic training and Garlic on TIMP-1. Timepoint: Before and after the protocol. Method of measurement: Biochemical and laboratory methods. Islamic Azad University Approved 2019-03-11 Sport Sciences Research Institute of Iran Tehran: Motahari Ave., Miramad St., No. 5th Lane Tehran Tehran Iran (Islamic Republic of)