IRCT201208241197N13 IRCT 2013-04-14 Vice chancellor for research, Tabriz University of Medical Sciences Whole fruit and medolla powder of Elaeagnus angustifolia effect on osteoarthritis Effect of whole fruit and medolla powder of Elaeagnus angustifolia supplementation on clinical manifestation, inflammatory factors, matrix metalloproteinase enzymes, oxidative stress and nutritional status of patients with knee osteoarthritis 2013-04-01 anticipated 90 Complete https://irct.ir/trial/408 interventional Randomization: N/A, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Other design features: This is a double blind study in which the researcher and patients will be blinded to the group assignments. The patients will receive the supplements by another person who is not involved in doing the assessment and chemical analysis. Patients will be informed about the type of supplements (whole fruit and medolla powder of Elaeagnus angustifolia and placebo) however they will not be aware about the group assignments. 3 knee osteoarthritis. Intervention 1: Intervention 1: Oral administration of 15 grams whole fruit powder of Elaeagnus angustifolia (prepared by the researcher) for 8 weeks. Intervention 2: Intervention 2: Oral administration of 15 grams medolla powder of Elaeagnus angustifolia (prepared by the researcher) for 8 weeks. Intervention 3: Intervention3: Oral administration of 15 grams corn starch+Isomaltose for 8 weeks.