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IRCT138902253930N1 IRCT 2010-11-24 Shiraz University of Medical Sciences Comparison of the efficacy of electroconvulsive therapy and repetitive transcranial magnetic stimulation on Major depressive disorder Comparison of the efficacy of electroconvulsive therapy and repetitive transcranial magnetic stimulation 2010-06-02 anticipated 60 Complete https://irct.ir/trial/4080 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 1 Condition 1: major depressive Disorder. Condition 2: Recurrent depressive disorder. Intervention 1: The patients in electroconvulsive therapy group receive 10 sessions (3 days per week). There are 3 sessions of electroconvulsive therapy in each week for each patient. Intervention 2: The patients in repetitive transcranial magnetic stimulation group receive repetitive transcranial magnetic stimulation daily for 10 days (Saturday to Wednesday). Each session is 10 minutes with a large figure of eight coil. http://www.ncbi.nlm.nih.gov/pubmed/?term=ghanizadeh+ect+rtms INTRODUCTION: <br /> <br /> Studies comparing the antidepressant effects of electroconvulsive therapy (ECT) and repetitive transcranial magnetic stimulation (rTMS) have reported mixed results. This study compared the efficacy of rTMS and ECT in adult patients with refractory major depressive disorder (MDD).<br /> <br /> METHODS: <br /> <br /> This randomized, ECT-controlled, parallel-group clinical trial analyzed the antidepressant effects of ECT and rTMS in 73 patients with MDD diagnosed according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria. The Beck Depression Inventory and Hamilton Depression Rating Scale were used to measure depression.<br /> <br /> RESULTS: <br /> <br /> Both ECT and rTMS significantly improved depression and suicidal behavior scores. However, ECT reduced depression and suicidal behavior scores more than rTMS. There were no significant adverse effects in the rTMS group.<br /> <br /> DISCUSSION: <br /> <br /> Both ECT and rTMS improved MDD in the short term, but the antidepressant efficacy of ECT was greater than rTMS. Moreover, ECT led to greater reductions in suicidal behavior than rTMS. Until strong evidence for the safety and efficacy of rTMS is available, further studies are needed to compare ECT and rTMS in terms of the long-term relapse rate and quality of life.<br />
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scientific Ahmad Ghanizadeh
Shiraz- Chamran street- Hafez Hospital
Shiraz Iran (Islamic Republic of) -- +98 71 1627 3070 ghanizad@sina.tums.ac.ir Shiraz University of Medical sciences Iran (Islamic Republic of) Inclusion: 1- major depressive disorder, 2- age>20, 3- voluntary participation. Exclusion: 1-bipolar mood disorder, 2- serious medical conditions, 3- suicidal attempt, 4- lack of consent. 19 years 65 years Both F32 F33 Depressive episode Recurrent depressive disorder Treatment - Other Treatment - Other The patients in electroconvulsive therapy group receive 10 sessions (3 days per week). There are 3 sessions of electroconvulsive therapy in each week for each patient The patients in repetitive transcranial magnetic stimulation group receive repetitive transcranial magnetic stimulation daily for 10 days (Saturday to Wednesday). Each session is 10 minutes with a large figure of eight coil Depression score. Timepoint: before and after 10 sessions of intervention. Method of measurement: Questionnaire. Shiraz University of Medical Sciences Approved 2010-06-02 Shiraz University of Medical Sciences Shiraz- Chamran street- Hafez hospital Shiraz Iran (Islamic Republic of)