IRCT201108193930N11 IRCT 2011-09-18 Vice chancellor for research, Shiraz University of Medical Sciences The effect of short-term co-administration of folate on aggressive behaviors in Attention Deficit Hyperactivity Disorder The effect of short-term co-administration of folate on aggressive behaviors in Attention Deficit Hyperactivity Disorder (ADHD): a double blind randomized controlled trial 2011-08-19 anticipated 40 Complete https://irct.ir/trial/4090 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2-3 Attention Deficit Hyperactivity Disorder (ADHD). Intervention 1: folic acid (5mg/day). Intervention 2: Placebo.

public

scientific Ahmad Ghanizadeh

Hafez Hospital, Chamran Street

Shiraz Iran (Islamic Republic of) +98 71 1627 3070 ghanizad@sina.tums.ac.ir Shiraz University of Medical sciences Iran (Islamic Republic of) Inclusion criteria: Diagnosis of Attention Deficit Hyperactivity Disorder (ADHD) according to DSM-IV diagnostic criteria; children and adolescents aged 7 to 19 years old. Exclusion criteria: Self reported an allergic reaction to folic acid; kidney disease; being on dialysis; infection; anemia; epilepsy; taking medications such as phenytoin, methotrexate, nitrofurantoin, tetracycline barbiturates such as Phenobarbital, primidone; lack of providing written informed consent for participation; a diagnosed psychotic disorder; extensive use of nutritional folic acid supplements within the previous 3 months; behavior therapy or any other psychotherapy in the last three months or during this study. 7 years 19 years Both F 90 Hyperkinetic disorders Treatment - Drugs Placebo folic acid (5mg/day) Placebo ADHD rating questionnaire. Timepoint: evey 30 days. Method of measurement: parent report. Modified Overt Aggression Scale. Timepoint: evey 30 days. Method of measurement: parent report. Vice chancellor for research, Shiraz University of Medical Sciences Approved 2011-07-12 Ethics committee of Shiraz University of Medical Sciences Vice-chancellery of Research Affairs, Shiraz University of Medical sciences, Zand Street Shiraz Iran (Islamic Republic of)