IRCT20130713013976N7 IRCT 2019-09-08 Hamedan University of Medical Sciences Effect of Aloe vera in Adenotonsillectomy pain reduction Study of the efficacy of aloe vera mouthwash on reduction of post Adenotonsillectomy pain in 5-12 years old children referred to Behesht Hospital of Hamedan in 2019 : three blind randomized clinical trial 2018-09-23 anticipated 220 Complete https://irct.ir/trial/41058 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: This activity was performed by a pharmacist colleague. For this purpose, quadratic block randomization was used. Therefore, four sheets of paper were prepared and written on two letters A (for Aloe vera group) and two other letters N (for normal saline). The sheets were mixed together and placed in a drawer. One of the sheets was randomly drawn out and assigned to one of two groups (aloe vera or normal saline) whether the paper was assigned to as A or N and thus each group of normal saline and aloe vera bottles was randomly numbered from one to one hundred and twenty. It should be noted that the extruded sheets were not returned to the drawer until all four sheets were removed, and after all the four sheets were randomly removed, all the sheets were returned to the drawer again and the above operation was carried out for another four bottles until one hundred. And ten cases from each group continued, Blinding description: In this study, the shape of both bottles (aloe vera and placebo) was identical and was coded by a randomized four-block method. Bottle distributors (researchers), patients and the person performing the statistical analysis were not aware of the nature of the substance in the bottle, and after completing the data analysis and identifying the results, the drug code was decoded and the affect of each drug was identified and recorded. 3 Adenotonsillar hypertrophy. Intervention 1: Intervention group: The surgical site was washed. Then 10 cc of Aloe vera mouth wash was applied 1 minute before the surgery and the same amount right after surgery. The mouth wash was used 5 cc 3 times a day for 5 days. Intervention 2: Control group: The surgical site was washed. Then 10 cc of normal saline mouth wash was applied 1 minute before the surgery and the same amount right after surgery. The mouth wash was used 5 cc 3 times a day for 5 days. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information