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IRCT20180526039848N1 IRCT 2020-07-12 Mashhad University of Medical Sciences Treatment of cutaneous leishmaniasis with thymol loaded chitosan gel cutaneous leishmaniasis Evaluation of the treatment of cutaneous leishmaniasis with thymol loaded chitosan gel, as topical supplemental therapy (A RCT study) 2020-04-08 anticipated 50 Complete https://irct.ir/trial/41093 interventional Randomization: Not randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Blinding description: Those who evaluate the outcome are different from those who give the drug to the patient (the doctor gives the medicine) and the consequences will only be written by the code on a separate sheet (the consequences by the code introduced by the student). The statistician does not know any of the groups and does not know the type of treatment and will only do statistical work with specific codes. 2-3 Cutaneous leishmaniasis. Intervention 1: Intervention Group 1: Includes ten people with 2% chitosan gel in one of the wounds plus glucantime to increase the effectiveness compared to the other wound of the patient who is treated only with glucantime. Intervention 2: Intervention Group 2: Includes ten people with 5% chitosan gel in one of the wounds plus Glucantime to increase the effect compared to the other wound of the patient who is treated only with Glucantime. Intervention 3: Intervention Group 3: Includes ten individuals with the appropriate percentage of chitosan gel from the two primary intervention groups in combination with 5% thymol in one of the wounds locally plus glucantime to increase the effective effect compared to the patient's other wound only It is treated with glucantime, it is done. Intervention 4: Intervention Group 4: Includes ten individuals with the appropriate percentage of chitosan gel from the two primary intervention groups in combination with 10% thymol in one of the wounds locally plus glucantime to increase the effective effect compared to the patient's other wound only It is treated with glucantime, it is done. Intervention 5: Intervention Group 5: Includes ten individuals with the appropriate percentage of chitosan gel from the two primary intervention groups in combination with 15% thymol in one of the wounds locally plus glucantime to increase the effective effect compared to the patient's other wound only It is treated with glucantime, it is done. Yes - There is a plan to make this available What will be shared: All images of patients' wounds during treatment When: Up to two years after the completion of the project To whom: Project collaborators Conditions: Have a face-to-face conversation with project executives about your idea Where to obtain: Have a written request or in person with the project executors How to obtain: A written request should be given to the executors of the project Comments:
public Bibi Razieh Hosseini Farash
Department of Parasitology and Mycology, Faculty of Medicine, Mashhad University
Mashhad Iran (Islamic Republic of) 9177948564 +98 51 3800 2454 HoseiniFR@mums.ac.ir Mashhad University of Medical Sciences scientific Bibi Razieh Hosseini Farash
Azadi Square. Medical faculty
Mashhad Iran (Islamic Republic of) 9177948564 +98 51 3800 2454 HoseiniFR@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) There are at least two lesions, in one case intervention + glucantime and in the other lesion only glucantime is prescribed. 15 to 60 years Skin lesions at least one centimeter in size Leishmaniasis confirmed by a parasitologist consent signature 15 years 60 years Both People who do not use the drug according to the plan People who do not go to the clinic on the scheduled days B55.1 Cutaneous leishmaniasis Treatment - Drugs Treatment - Drugs Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention Group 1: Includes ten people with 2% chitosan gel in one of the wounds plus glucantime to increase the effectiveness compared to the other wound of the patient who is treated only with glucantime. Intervention Group 2: Includes ten people with 5% chitosan gel in one of the wounds plus Glucantime to increase the effect compared to the other wound of the patient who is treated only with Glucantime. Intervention Group 3: Includes ten individuals with the appropriate percentage of chitosan gel from the two primary intervention groups in combination with 5% thymol in one of the wounds locally plus glucantime to increase the effective effect compared to the patient's other wound only It is treated with glucantime, it is done Intervention Group 4: Includes ten individuals with the appropriate percentage of chitosan gel from the two primary intervention groups in combination with 10% thymol in one of the wounds locally plus glucantime to increase the effective effect compared to the patient's other wound only It is treated with glucantime, it is done Intervention Group 5: Includes ten individuals with the appropriate percentage of chitosan gel from the two primary intervention groups in combination with 15% thymol in one of the wounds locally plus glucantime to increase the effective effect compared to the patient's other wound only It is treated with glucantime, it is done Measuring the lesion diameter (millimeters) using image processing software. Timepoint: From the first week of treatment and patient visit the clinic for the first time (once every three days to 45 days). Method of measurement: processing software. Mashhad University of Medical Sciences Approved 2019-02-05 Ethics Committee of Mashhad University of Medical Sciences Azadi aquare Mashhad Razavi Khorasan Iran (Islamic Republic of)