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IRCT20190729044367N1 IRCT 2020-08-31 Islamic Azad University Comparison the effects of Acetaminophen and Ibuprofen on emotions Comparison the effects of Acetaminophen and Ibuprofen on emotions by recording electrical activity of the brain 2020-08-05 anticipated 54 Complete https://irct.ir/trial/41140 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Crossover, Purpose: Education/Guidance. 2 Healthy volunteers. In the first stage, participants are given a brain signal for each emotional state (happiness-sadness-neutral) while listening to a three-minute music. Before and after listening to music, each person fills out a questionnaire according to their feelings. In the second stage, the signal is recorded by receiving acetaminophen (500) mg of Rouz Darou Pharmaceutical Company while listening to the mentioned music. Before and after listening to music, each person fills out the questionnaire according to their feelings. In the third stage, the signal is recorded by receiving ibuprofen (400 mg) from Dana Pharmaceutical Company while listening to the music. . Before and after listening to music, each person fills out a questionnaire according to their feelings.. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is It's the information of participants and I haven't been allowed to publish them.
public Neda Kaffash
No. 48, Golestan8, AbazarBlvd, Sadeghie Sq.
Tehran Iran (Islamic Republic of) 1471773161 +98 21 4401 2937 neda.kaffash@yahoo.com Islamic Azad University scientific Maryam Farasatinasab
, School of Pharmacy-International Campus. Kazem Besarati St. Kabiri Tameh Ave. Shahid Hemmat Expy
Tehran Iran (Islamic Republic of) 1471773161 +98 21 4401 2937 maryfarasati@gmail.com Iran University of Medical Sciences Iran (Islamic Republic of) All participants should be right-handed They have normal hearing sensitivity No reported history of brain diseases like depression or alzheimer. No head trauma, stroke or injury Do not have history of alcohol and smoking (especially a few days before the signal is recorded) 18 years 35 years Both Pregnancy Breastfeeding Preexisting neurological or psychological disorders Severe liver failure based on Child-Pugh Score Renal failure (Glomerular Filtration Rate (GFR) < 15 mL/min) History of prior anti-psychotic or anti-epileptic use Allergy to oral Acetaminophen and non-steroidal anti-inflammatory drug (NSAID) History of smoking or alcohol abuse R45.89 Other symptoms and signs involving emotional state N/A In the first stage, participants are given a brain signal for each emotional state (happiness-sadness-neutral) while listening to a three-minute music. Before and after listening to music, each person fills out a questionnaire according to their feelings. In the second stage, the signal is recorded by receiving acetaminophen (500) mg of Rouz Darou Pharmaceutical Company while listening to the mentioned music. Before and after listening to music, each person fills out the questionnaire according to their feelings. In the third stage, the signal is recorded by receiving ibuprofen (400 mg) from Dana Pharmaceutical Company while listening to the music. . Before and after listening to music, each person fills out a questionnaire according to their feelings. Emotional arousal score in questionnaire between 0-5. Timepoint: Survey the emotional state immediately after the recording for checking the effect of painkiller. Method of measurement: Asking participants after recording and score the music from 0-5. and observe and analyze brain signals in both happiness and sadness. None Approved 2020-01-19 Ethics comittee of Iran University of Medical Sciences Iran University Of Medical Sciences Tehran Tehran Iran (Islamic Republic of)