IRCT138902263936N1 IRCT 2012-01-08 Isfahan University of Medical Sciences. The effect of red clover on menopausal symptoms The effects of red clover on some of menopausal symptoms and quality of life in post-menopausal women under coverage of Isfahan’s selected health care center in 2010 2010-10-23 anticipated 72 Complete https://irct.ir/trial/4121 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: Other Inclusion criteria: No use of treatments such as hormone therapy, dietary supplementations, herbal therapy in the six months prior to enrollment for relieving menopause symptoms, Interest in participation in the study. Other non-inclusion criteria and exclusion: The incidence of menopause at the ages under 40 years, Current treatment or therapy in the last 3 months with any of the following drugs: anticonvulsants, antidepressants, phenothiazines, benzodiazepines, ergot derivatives, -blockers, central acting antihypertensive drugs,Vegetarian, Current participation in any other clinical trial, Disorder in the metabolism or sensitivity to estrogen or phytoestrogens (this criterion was assessed with asking the questions about record of using OCPs and incidence of any problem following the consumption of these pills).BMI 25kg/ m2, having any type of disease, Unwillingness to continue participation in the study, Occurrence of any serious event especially one that could affects the quality of life during the study, Occurrence of any potential complication during the study that could affect the subject's health. The data were collected in four phases: at the beginning of the study, at the end of the second, sixth and tenth weeks of study. Before the treatment and at the end of the study, menopause specific quality of life questionnaire (MENQOL) was completed in the two groups. Furthermore, menopausal symptoms weekly were recorded using KMI by the study subjects. The subjects were asked to bring the container at the final visit and thus the number of the remained capsules could be counted by one of the health care center’s staff who was not informed about the study process. The study subjects were explained to avoid supplements containing soy more than once a week. During the medication consumption, which continued from end of the second week to end of the tenth week, the study subjects recorded their symptoms and were phone called weekly and regular drug consumption was reminded to them. Besides, phone number of the researcher also was given to the study subjects to contact the researcher. N/A Symptoms such as flushing, sleeplessness, headache, lack of concentration, associated with menopause. Intervention 1: Daily oral consumption one 45 mg red clover capsule each morning with the breakfast meal for 8 weeks continued from end of the second week to end of the tenth week. Intervention 2: In the control group: Daily oral consumption one 45 mg starch powder capsule each morning with the breakfast meal for 8 weeks continued from end of the second week to end of the tenth week.