IRCT20190803044426N1 IRCT 2019-12-25 Iran University of Medical Sciences Efficacy of Aloe Vera gel in systolic heart failure Evaluation the efficacy of “Aloe Vera” oral gel on the quality of life in patients with systolic heart failure : A double blind, randomized controlled trial 2019-12-11 anticipated 26 Complete https://irct.ir/trial/41286 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The block randomization method is used Blocking is used to balance the number of samples assigned to each study group, because we have two intervention groups, use equal 4 blocks and create all 4 possible modes and then with Excel software we randomly select a number of blocks. Since the sample size in this study is 26 cases (13 cases in each group), by using Excel software, 7 blocks of 4 are randomly used. The label of interventions to one of the letters A or B and the sequence of randomization determined by the statistical consultant. For allocation concealment,drug delivery and the sequence of randomization is not available to researchers and evaluators while is the responsibility of the off-site individual, Blinding description: After evaluation by the researcher, participants are referred to the off-site individual(drug Delivery Person) and receive A or B intervention according to a random sequence list The drug and placebo are coded in similar capsules and in identical packages, with the same color and participants, researchers, drug Delivery Person and investigators are not aware of treatment allocation. Only the statistician will be unblinded to the treatment assignment. 3 Systolic heart failure. Intervention 1: Patients will receive Aloe Vera gel capsule two times a day for next 8 weeks.Each capsule contains 150 mg of Aloe Vera gel . The drug will be provided by Shahid Beheshti university pharmacy lab. Intervention 2: Placebo capsule that is identically appearing with Aloe Vera capsule will be administered to patients in placebo group. patients will receive placebo drug two times a day for next 8 weeks. Capsules contain 150 mg starch which will be provided in the Shahid Beheshti university pharmacy lab. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information