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IRCT20190626044020N1 IRCT 2019-12-29 Esfahan University of Medical Sciences Comparative Study on the Effect of two Labetalol-Nitroglycerine Combinations withLabetalol-Hydralazine on volume blood loss During Ducriocysturinostomy with Local Anesthesia Comparative Study on the Effect of two Labetalol-Nitroglycerine Combinations withLabetalol-Hydralazine on volume blood loss During Ducriocysturinostomy with Local Anesthesia 2018-03-21 anticipated 70 Complete https://irct.ir/trial/41345 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization method: Simple randomization Randomization Unit: Individual Randomization Tool: Random Number Table, Blinding description: Blindness is that after giving the patient complete information. If there are no criteria for exclusion, the patient will be entered into the study after obtaining informed consent. The patient is not informed about the type of medication used during the study. They also do not know the type of medication used when assistants and health care providers gather information. N/A stenosis and insufficiency of lacrimal passages. Intervention 1: Intervention group 1: After the patient is placed on the baseline monitoring bed including systolic blood pressure, diastolic blood pressure, heart rate and respiratory rate. Then, local anesthesia will be performed by the surgeon using 8 cc lidocaine 2% in both groups. Both groups are given a boletabolol dose of 20 mg within 2 minutes. Doses and rate of intravenous injection are selected based on the policy for hypertension crisis. Then the infusion of labetalol at a rate of 0.5 - 1 mg / min and the maximum dose received will be 300 mg. Group A patients start intravenous infusion of Tri-nitroglycerin 15 - 20 mcg / min from the lower limit and increase every 5 minutes if necessary to reach target MAP. Intervention 2: Intervention group 1: After the patient is placed on the baseline monitoring bed including systolic blood pressure, diastolic blood pressure, heart rate and respiratory rate. Then, local anesthesia will be performed by the surgeon using 8 cc lidocaine 2% in both groups. Both groups are given a boletabolol dose of 20 mg within 2 minutes. Doses and rate of intravenous injection are selected based on the policy for hypertension crisis. Then the infusion of labetalol at a rate of 0.5 - 1 mg / min and the maximum dose received will be 300 mg. In group B, hydralazine is given 0.5 - 1 mg / min intravenous infusion. The level starts from the lower limit if necessary, increasing every 5 minutes to achieve target MAP. No - There is not a plan to make this available Justification or reason for not sharing IPD is Confidentiality of information
public Dr Syed Morteza Heydari
Daneshgah street, Isfahan University of Medical Sciences
Esfahan Iran (Islamic Republic of) 8174643446 +98 31 3445 7701 M_heidari@med.mui.ac.ir Esfahan University of Medical Sciences scientific Dr Syed Morteza Heydari
Daneshgah street, Isfahan University of Medical Sciences
Esfahan Iran (Islamic Republic of) 8174643446 +98 31 3668 5555 M_heidari@med.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) Patients undergoing DCR surgery who are not contraindicated with hydralazine, tri-nitroglycerin, and labetalol, aged 18 to 80 years Patient Satisfaction for Inclusion 18 years 80 years Both Known allergies to medicines Heart disease Diabetes mellitus, obvious anemia Hemoglobinopathy Polycythemia Liver disease Cerebrovascular ischemic disease H04.5 stenosis and insufficiency of lacrimal passages Treatment - Drugs Treatment - Drugs Intervention group 1: After the patient is placed on the baseline monitoring bed including systolic blood pressure, diastolic blood pressure, heart rate and respiratory rate. Then, local anesthesia will be performed by the surgeon using 8 cc lidocaine 2% in both groups. Both groups are given a boletabolol dose of 20 mg within 2 minutes. Doses and rate of intravenous injection are selected based on the policy for hypertension crisis. Then the infusion of labetalol at a rate of 0.5 - 1 mg / min and the maximum dose received will be 300 mg. Group A patients start intravenous infusion of Tri-nitroglycerin 15 - 20 mcg / min from the lower limit and increase every 5 minutes if necessary to reach target MAP. Intervention group 1: After the patient is placed on the baseline monitoring bed including systolic blood pressure, diastolic blood pressure, heart rate and respiratory rate. Then, local anesthesia will be performed by the surgeon using 8 cc lidocaine 2% in both groups. Both groups are given a boletabolol dose of 20 mg within 2 minutes. Doses and rate of intravenous injection are selected based on the policy for hypertension crisis. Then the infusion of labetalol at a rate of 0.5 - 1 mg / min and the maximum dose received will be 300 mg. In group B, hydralazine is given 0.5 - 1 mg / min intravenous infusion. The level starts from the lower limit if necessary, increasing every 5 minutes to achieve target MAP. Determination of the mean volume of bleeding in Dacryocystorhinostomy to CC. Timepoint: The volume of blood collected in the suction device at the end of surgery. Method of measurement: Blood collected in suction to cc. Esfahan University of Medical Sciences Approved 2018-06-27 Ethics Committee of Isfahan University of Medical Sciences Daneshgah street, Isfahan University of Medical Sciences Esfahan Isfehan Iran (Islamic Republic of)