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IRCT20190804044432N1 IRCT 2019-08-18 Zahedan University of Medical Sciences Comparing neostigmine and metoclopramide on gastric residual volume Comparing the effect of intravenous neostigmine and metoclopramide on gastric residual volume of mechanically ventilated intensive care unit patients 2019-09-08 anticipated 100 Complete https://irct.ir/trial/41382 interventional Randomization: Not randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Blinding description: This means that patients in groups do not know the used drugs, and drugs has similar packaging. 3 dilatation of volume. Intervention 1: Intervention group: In the first group, neostigmine, manufactured by Caspian Tamin Pharmaceutical Company, was used at 2.5 mg / 100 ml of normal saline, intravenously and one time. Intervention 2: Intervention group: In the second group used metoclopramide, manufactured by Caspian Tamin Pharmaceutical Company, at a dose of 10 mg / 100 ml of normal saline, intravenously and one time. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information
public Sara Saneie Moqadam
9816743463, Zahedan University of Medical Sciences, Dr. Hesabi Square, Persian Gulf Blvd, Zahedan, Sistan and Baluchestan
Zahedan Iran (Islamic Republic of) 9816743463 +98 54 3329 5725 m_Shahrakim@zaums.ac.ir Zahedan University of Medical Sciences scientific Sara Saneie Moqadam
9816743463, Zahedan University of Medical Sciences, Dr. Hesabi Square, Persian Gulf Blvd, Zahedan, Sistan and Baluchestan
Zahedan Iran (Islamic Republic of) 9816743463 +98 54 3329 5725 m_Shahrakim@zaums.ac.ir Zahedan University of Medical Sciences Iran (Islamic Republic of) Age between 20 and 50 years Patients under mechanical ventilation Patients with enteral nutrition through nasogastric tube 20 years 50 years Both Previous use of beta blockers Heart Block Bradycardia (heart rate less than 60) before inclusion Hypothermia in the form of central temperature below 35 degrees Kidney Failure (CR> 1.5) Use Erythromycin or Cisapride within 8 hours before starting the study Recent surgery on stomach or digestive tract within the last ten days Signs and symptoms of bowel obstruction Pregnancy and lactation Active bronchospasm Extrapyramidal symptoms Sensitivity to Neostigmine Active gastrointestinal bleeding K31.0 Acute dilatation of stomach Treatment - Drugs Treatment - Drugs Intervention group: In the first group, neostigmine, manufactured by Caspian Tamin Pharmaceutical Company, was used at 2.5 mg / 100 ml of normal saline, intravenously and one time. Intervention group: In the second group used metoclopramide, manufactured by Caspian Tamin Pharmaceutical Company, at a dose of 10 mg / 100 ml of normal saline, intravenously and one time. Gastric residual volume. Timepoint: Before starting the drug infusion and 3, 6, 9 and 12 hours after the start of the infusion. Method of measurement: Aspirate with a gavage syringe. Zahedan University of Medical Sciences Approved 2019-07-27 Ethics committee of Zahedan University of Medical Sciences 9816743463, Zahedan University of Medical Sciences, Dr. Hesabi Square, Persian Gulf Blvd, Zahedan, Sistan and Baluchestan Zahedan Sistan-va-Balouchestan Iran (Islamic Republic of)