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IRCT201612253979N6 IRCT 2017-01-24 Research Devision, Ahvaz Jondishapoor Medical University Efficacy of pramipexole treatment and methylphenidate in children with attention deficit hyperactivity disorder, compared with placebo and methylphenidate. Attention Deficit Hyperactivity Disorder Efficacy of pramipexole treatment and methylphenidate in children with attention deficit hyperactivity disorder, compared with placebo and methylphenidate. 2017-02-19 anticipated 10 Complete https://irct.ir/trial/4156 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2-3 attention deficit hyperactivity disorder. Intervention 1: Intervention group: children treat with methylphenidate and pramipexole during 6 weeks. The starting dose of methylphenidate considered to be 0.3mg / kg in two divided doses and increase to 1mg/kg based on need. Pramipexole starts with dose of 0.125mg in nights Then gradually increase the dose based on clinical response and tolerability of side effects. The final dose of up to 0.5mg pramipexole a day. Intervention 2: Treatment groups: children 6 weeks will be treated with methylphenidate and placebo. Placebo pill shape, color, smell and taste will be like pramipexole.
public Forough Riahi
Ahvaz Golestan Hospital, Ahvaz
Ahvaz Iran (Islamic Republic of) +98 61 3374 3038 riahi13@gmail.com Ahvaz Jundishapur University of Medical Sciences scientific Forough Riahi
Ahvaz Golestan Hospital, Ahvaz
Ahvaz Iran (Islamic Republic of) +98 61 3374 3038 riahi13@gmail.com Ahvaz Jundishapur University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Children 6-12 years old;Having diagnostic criteria and testing Connors. Exclusion criteria: medical conditions such as kidney failure and epilepsy;psychiatric disorders with a focus on DSM IV-TR; mental disability;history of seizures other than seizures associated with fever,need for dopaminergic drugs, levodopa, ranitidine, cimetidine 6 years 12 years Both F90.0 Disturbance of activity and attention Treatment - Drugs Treatment - Drugs Intervention group: children treat with methylphenidate and pramipexole during 6 weeks. The starting dose of methylphenidate considered to be 0.3mg / kg in two divided doses and increase to 1mg/kg based on need. Pramipexole starts with dose of 0.125mg in nights Then gradually increase the dose based on clinical response and tolerability of side effects. The final dose of up to 0.5mg pramipexole a day. Treatment groups: children 6 weeks will be treated with methylphenidate and placebo. Placebo pill shape, color, smell and taste will be like pramipexole. Attention Deficit Hyperactivity Disorder. Timepoint: Befor intervention- the end of second, fourth and sixth weeks of the study. Method of measurement: The Conner's parent rating scale. Research Devision, Ahvaz Jondishapoor Medical University Approved 2016-07-23 Ahvaz JundiShapour University of Medical Sciences Ethics Committee Golestan Blvd- Ahvaz Ahvaz Iran (Islamic Republic of)