]>
IRCT20110731007165N7 IRCT 2019-09-10 Tehran University of Medical Sciences Effect of intrauterine administration of granulocyte-colony stimulating factor (GCSF) in IVF cycles on the fertility rate of infertile women Effect of intrauterine administration of granulocyte-colony stimulating factor (GCSF) in IVF cycles on the fertility rate of infertile women suffering from moderate to severe endometriosis 2019-01-15 anticipated 66 Complete https://irct.ir/trial/41694 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Our sample size is 66 people, with 33 people in each group.patients were allocated by simple randomization.In this method RANDBETWEEN function in the Excel program is used to generate a random number between 1 and 2. This is repeated 66 times. 3 Infertility. Intervention 1: Intervention: Immediately after ovarian puncture, 300µ GCSF is injected into the uterine cavity. Intervention 2: Control group: no intervention. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is It is not yet known if there will be a plan to make this available
public Dr. Ladan Kashani
Arash Hospital, Rashid Street, Tehran Pars
Tehran Iran (Islamic Republic of) 1653915981 +98 21 7788 3195 Kashani_ladan@tums.ac.ir Tehran University of Medical Sciences scientific Dr. Ladan Kashani
Arash Hospital, Rashid Street, Tehran Pars
Tehran Iran (Islamic Republic of) 1653915981 +98 21 7788 3195 Kashani_ladan@tums.ac.ir Tehran University of Medical Sciences Iran (Islamic Republic of) First time IVF due to infertility Moderate to severe endometriosis (according to laparoscopic criteria, moderate endometriosis was defined as Adhesion affecting Fallopian tubes or ovaries, and severe endometriosis was defined as the involvement of Fallopian tubes, ovaries, and cul-de-sac) Age 18-40 years Fertility due to endometriosis Moderate -to –severe endometriosis was characterized by endometrial glands and stroma at least 5 mm beneath the peritoneum or an ovarian endometriotic cyst (endometrioma) 18 years 40 years Female Male factor infertility. Evidence of a significant decrease in the ovarian reserve (FSH>11, AMH<0.5, decreased AFC), Endocrine disorders (diabetes, thyroid diseases, hyperprolactinemia, hypothalamic amenorrhea, etc.) , confirmed medical and immunologic diseases (SLE, rheumatoid arthritis, antiphospholipid syndrome, cardiovascular, liver, and renal diseases), and congenital uterine anomalies and uterine cavity disorder (bicornuate uterus, unicornuate uterus, Asherman syndrome, myoma, polyps, etc.). Donation candidates (ovum donation and surrogate utrus) were also excluded from the study N97.8 Female infertility of other origin Treatment - Drugs N/A Intervention: Immediately after ovarian puncture, 300µ GCSF is injected into the uterine cavity Control group: no intervention Clinical pregnancy. Timepoint: 3 weeks after embryo transfer. Method of measurement: Vaginal ultrasound. Tehran University of Medical Sciences Approved 2019-01-12 Ethics Committee of Tehran University of Medical Sciences Qods St, Keshavarz Blvd, Tehran, Iran Tehran Tehran Iran (Islamic Republic of)