IRCT20190819044566N1 IRCT 2019-09-18 Shahid Beheshti University of Medical Sciences Effect of Dexmedtomidine on postoperative pain in third molar surgery The effect of Dexmedtomidine plus Bupivacaine on postoperative pain in mandibular third molar Surgery. 2019-10-22 anticipated 60 Complete https://irct.ir/trial/41697 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Factorial, Purpose: Treatment, Randomization description: In this study, random allocation software was used for simple randomization.after allocation in 2 groups with 20 persons, concealed in sequentially numbered, sealed, opaque envelopes, Blinding description: After informing patients of their study and consenting to this study, they are divided into two groups to reduce bias for intervention and outcome evaluation in a double-blind manner so that patients are divided into two groups of one and two without knowledge of membership in which group, they receive surgery. Neither the study nor the observer knows who will be in which group. 3 Post dental surgery pain. Intervention 1: Intervention group: subjects receive a mixture of Bupivacaine 0.5% (1.8 ml) with epinephrine 1:200000 (Novocal Pharmucautical of Canada Inc. Cambridye, Ontario N1R6) and 0.5 mg/kg Dexmedetomidine (Exir co, Iran) through the inferior alveolar nerve block injection and immediately after surgeries.All subjects receive 400 mg Ibuprofen 1 hour before surgeries. Intervention 2: Control group:1.8 ml Bupivacaine 0.5% and Epinephrine 1:200000 is injected after surgeries for all subjects. All subjects receive 400 mg Ibuprofen 1 hour before surgeries. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is there is no additional information