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IRCT20110731007165N8 IRCT 2019-12-19 Tehran University of Medical Sciences repeated gonadotropin-releasing hormone agonist (GnRH-a) versus low dose human chorionic gonadotropin (HCG) Comparison of the efficacy of repeated gonadotropin-releasing hormone agonist (GnRH-a) versus adding low dose human chorionic gonadotropin (HCG) for ovulation induction in patients with polycystic ovary syndrome undergoing IVF/ICSI 2019-12-31 anticipated 60 Complete https://irct.ir/trial/41780 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The statistician will divide eligible participants into two groups by using block randomization method. The size of the blocks in this study will be six. The randomization tool used in this study is sealed envelopes that will be prepared by the statistician. 3 Infertility associated with polycystic ovarian syndrome. Intervention 1: First Intervention group (Group A): Subcutaneous injection of 0.2mg Decapeptyl ampoule (GnRH-a) that will be repeated with a half-dose after 12 hr. Intervention 2: Second Intervention group (Group B): Subcutaneous injection of 0.2 mg Decapeptyl ampoule (GnRH-a) with 2000 units of HCG ampoule. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is The research team has not yet made a decision on how the data will be released.
public Dr. Mahdiyeh Sadat Portabatabaei
No. 162 َAlley (Abdul Majid), Shahid Baghdarnia Street (North Rashid), Shahid Bagheri Highway, Resalat Highway, Tehran, Iran
Tehran Iran (Islamic Republic of) 1653915981 +98 21 7771 9922 prtbtbaeim@gmail.com Arash Women 's Hospital scientific Dr. Ladan Kashani
No. 162 َAlley (Abdul Majid), Shahid Baghdarnia Street (North Rashid), Shahid Bagheri Highway, Resalat Highway, Tehran, Iran
Tehran Iran (Islamic Republic of) 1653915981 +98 21 7788 3195 Kashani_ladan@tums.ac.ir Tehran University of Medical Sciences Iran (Islamic Republic of) Aged between 18-38 years old Body mass index below 30 and above 19 kg/m2 Normal uterine cavity Ovulation induction by GnRH antagonist cycle regimen 18 years 38 years Female Repeated implantation failure WHO 1 group Using Percutaneous Epididymal Sperm Aspiration (PESA) or testicular sperm extraction (TESE) History of taking oral contraceptive pills for more than three months before the IVF Endocrinopathies E28.2 Polycystic ovarian syndrome Treatment - Drugs Treatment - Drugs First Intervention group (Group A): Subcutaneous injection of 0.2mg Decapeptyl ampoule (GnRH-a) that will be repeated with a half-dose after 12 hr Second Intervention group (Group B): Subcutaneous injection of 0.2 mg Decapeptyl ampoule (GnRH-a) with 2000 units of HCG ampoule Ovarian hyperstimulation syndrome (OHSS). Timepoint: At the end of the study. Method of measurement: Hospital records. Metaphase II (MII) oocytes. Timepoint: At the end of the study. Method of measurement: Hospital records. Total Number of oocytes. Timepoint: At the end of the study. Method of measurement: Hospital records. Number of embryos. Timepoint: At the end of the study. Method of measurement: Hospital records. Endometrial thickness. Timepoint: At the time of embryo transfer. Method of measurement: Vaginal Ultrasound. Embryos quality. Timepoint: At the end of the study. Method of measurement: Hospital records. Tehran University of Medical Sciences Approved 2019-09-02 Ethics Committee of Tehran University of Medical Sciences Qods St, Keshavarz Blvd, Tehran, Iran Tehran Tehran Iran (Islamic Republic of)