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IRCT138903034010N1 IRCT 2010-06-22 Avicenna Research Institute and National Institute of Nutrition Research Comparison of the effect of folic acid and 5-methyltetrahydrofolate (5MTHF) on serum folat and homocysteine levels, and abortion rates in women suffering from recurrent abortion Comparison of the effect of folic acid and 5-methyltetrahydrofolate (5MTHF) on serum folat and homocysteine levels, and abortion rates in women suffering from recurrent abortion 2010-06-22 anticipated 60 Complete https://irct.ir/trial/4184 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2 recurrent abortion. Intervention 1: 5 methyltetrahydrofolate (Intervention, 5 mg, 7 months). Intervention 2: folic acid (control, 5mg, 7 months).
public Azita Hekmatdoost
West Arghavan, Shahrak Gharb
Tehran Iran (Islamic Republic of) +98 21 2293 0824 a_hekmat2000@yahoo.com Dep Human Nutrition, Shahid Beheshti University of Medical Sciences scientific Azita Hekmatdoost
West Arghavan, Shahrak Gharb
Tehran Iran (Islamic Republic of) +98 21 2293 0824 a_hekmat2000@yahoo.com Dep Human Nutrition Iran (Islamic Republic of) Inclusion criteria: Willing to participate in the study and filling out the informed consent form, History of 3 or more idiopathic abortion, the last one should be more than 6 months ago, no history of intaking folate supplements or high folate containing foods during last 6 months, All previous abortions should be idiopathic without any anatomic, cytologic, hormonal, septic pathologic finding, no special diets Exclusion criteria: elective or induced abortion, molar or ectopic pregnancies, presence of any malignancy, chromosomal abnormality, uterine abnormality, Thyroid, kidney, or liver dysfunction, Glucose intolerance, seizure, Alcohol or drug abuse, Taking any drug affecting homocystein metabolism, not following the study protocol. 18 years 50 years Female O03 spontaneous abortion Treatment - Drugs Treatment - Drugs 5 methyltetrahydrofolate (Intervention, 5 mg, 7 months) folic acid (control, 5mg, 7 months) Changes in recurrent abortion successful treatment. Timepoint: 20 weeks. Method of measurement: clinical and paraclinical findings. Serum folate level. Timepoint: 8 weeks. Method of measurement: ELISA. Serum Homocystein level. Timepoint: 8 weeks. Method of measurement: ELISA. Avicenna Research Institute and National Institute of Nutrition Research Approved 2009-09-23 Avicenna Ethics Committee Avicenna Reserch Institute Tehran Iran (Islamic Republic of)