IRCT20180213038720N2 IRCT 2019-12-18 Bagheiat-allah University of Medical Sciences A survey of the effect of ozonated water mouthwash on oral health and incidence of ventilator-associated pneumonia in patients connected to mechanical ventilation A survey of the effect of ozonated water mouthwash on oral health and incidence of ventilator-associated pneumonia in patients connected to mechanical ventilation in intensive care units - A randomized clinical trial 2019-09-23 anticipated 78 Complete https://irct.ir/trial/41951 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: Randomization is planned to be performed using quadruple-block random allocation method to conduct experiments in two groups using chlorhexidine and ozonated water as mouthwash. The patients will be included in the study and grouped under either of the two groups using SNOSE (Sequentially numbered, sealed, opaque envelopes) allocation concealment and the designed quadruple blocks by a statistics expert, Blinding description: For the purpose of this study, the blinding will be performed as follows. Firstly, the resident at the ICU will group each patient under either of the two groups (chlorhexidine and ozonated water) using the designed quadruple blocks by a statistics expert. Next, trained nurses will administer, according to the respective protocol, the patients with the respective mouthwash without even knowing the type of the mouthwash. In the next stage, the researcher will undertake the mouth and teeth health inspection to see whether the ventilator-associated pneumonia (VAP) has occurred without no information on the grouping of the patients. Finally, once collected, the data will be analyzed by the statistics expert with no information about the group to which each patient belongs. 2 Condition 1: ventilator-associated pneumonia. Condition 2: oral health. Intervention 1: Intervention group: Firstly, inner surface of the mouth is thoroughly washed using a soft brush (for kids) on which 0.5 cm of fluoride-rich toothpaste is applied followed by a suction stage. Next, 15 mL of the ozonated water solution is used to wash all the surfaces across the entire mouth, lounge, and teeth using a sterilized syringe. After 30 seconds, the patient’s mouth is subjected to suction at a pressure of -100 mmHg for a maximum of 10 seconds followed by hyper-oxygenating the patient with 100% oxygen for 2 minutes. Intervention 2: Control group: Firstly, inner surface of the mouth is thoroughly washed using a soft brush (for kids) on which 0.5 cm of fluoride-rich toothpaste is applied followed by a suction stage. Next, 15 mL of the chlorhexidine 0.2 solution is used to wash all the surfaces across the entire mouth, lounge, and teeth using a sterilized syringe. After 30 seconds, the patient’s mouth is subjected to suction at a pressure of -100 mmHg for a maximum of 10 seconds followed by hyper-oxygenating the patient with 100% oxygen for 2 minutes. Yes - There is a plan to make this available What will be shared: Collected data will be given to the individuals or organizations -a raw information- that will be provided with the consent of the participants without any name, address or telephone number, and other items. When: After we have finished the study if data crashed or disposed it will be reachable in a raw information. To whom: Just those have a Written request from authoritative research organizations. Conditions: If there was need to be called in analysis field you can call 09116470641. Where to obtain: Mostafa Soodmand, phone number: 09116470641 How to obtain: After confirmation the requeste, only raw and unidentifiable information from the mail will be delivered within one week. Comments: If you have any question about this study call these numbers. 09116470641- 09155328439