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IRCT20180114038356N3 IRCT 2020-07-16 Kerman University of Medical Sciences Investigating the effects of berberis vulgaris L. on the treatment of opiate withdrawal syndrome Investigating the effects of berberis vulgaris L. on the treatment of opiate withdrawal syndrome 2019-04-19 anticipated 28 Complete https://irct.ir/trial/42001 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Block randomization. The size of each block was 4 people. In this way, the first block is given the capsule with code 1 and the second block is given the capsule with code 2 and the 3rd block is given the capsule with code 1 again and so on, Blinding description: The capsules were given to the treating physician with a code, and patients are not aware of the contents of the capsules. 2 Patients addicted to opioids treated with methadone. Intervention 1: Intervention group: 28 patients under methadone therapy will be assigned to the treatment group to receive the extract (500 mg, twice a day for 30 days). Intervention 2: Control group: 28 patients under methadone therapy will be assigned to the control group to receive the placebo (500 mg, twice a day for 30 days). Yes - There is a plan to make this available What will be shared: Part of the data, such as information about the main consequence or the like, can be shared. When: after publication To whom: people working in academic institutions or people working in businesses Conditions: meta analysis Where to obtain: Email of the main executor of the project How to obtain: Review the request by the project executor, consult with other colleagues, announce the result Comments:
public Somayyeh Karami-Mohajeri
Kerman University of Medical Sciences,Medical University Campus,Haft-Bagh Highway, Kerman, Iran
Kerman Iran (Islamic Republic of) 7616913555 +98 34 4142 5001 somayyehkarami@gmail.com Kerman University of Medical Sciences scientific Somayyeh Karami Mohajeri
Kerman University of Medical Sciences,Medical University Campus,Haft-Bagh Highway, Kerman, Iran
Kerman Iran (Islamic Republic of) 7616913555 +98 34 3132 5001 somayyehkarami@gmail.com Kerman University of Medical Sciences Iran (Islamic Republic of) Opioid addiction of at least 2.3 grams per day continuously for at least one year, Age between 20-60 years old No history of medical comorbidities No history of allergies to this plant 20 years 60 years Both History of medical comorbidities History of allergies to this plant Do not take the capsules Dissatisfaction with methadone dose reduction Intolerance to some of side effects of the extract, such as dry mouth F11 Mental and behavioural disorders due to use of opioids Treatment - Drugs Placebo Intervention group: 28 patients under methadone therapy will be assigned to the treatment group to receive the extract (500 mg, twice a day for 30 days). Control group: 28 patients under methadone therapy will be assigned to the control group to receive the placebo (500 mg, twice a day for 30 days). Examination of opioid withdrawal symptoms and neurological complications with the questionnaires. Timepoint: Before intervention and 7, 14 and 28 days after intervention. Method of measurement: Questionnaires. Assessment of depression, anxiety, sleep quality. Timepoint: Before intervention and 7, 14 and 28 days after intervention. Method of measurement: Questionnaires. Kerman University of Medical Sciences Approved 2018-05-12 Ethics Committee of Kerman University of Medical Sciences Ebn-e-Sina St., Jahad Blvd., Kernan, Iran Kerman Kerman Iran (Islamic Republic of)