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IRCT201610224025N8 IRCT 2016-11-22 Vice President of Research   Kermanshah University of Medical Sciences sublingual misoprostol on intraoperative blood loss prior to abdominal hysterectomy. Effect of sublingual misoprostol on intraoperative blood loss prior to abdominal hysterectomy. 2015-10-23 anticipated 60 Complete https://irct.ir/trial/4210 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Other. 1 Hysterectomy. Population study Will be divided into two groups. study group(Group 1) and control group (Group 2).In study group 2 pills equal to 400 mcg misoprostol and in control Group 2 pills vitamin B6 will be placed under the tongue one hour before the surgery.
public Dr Tayebe Noori
Kermanshah University of Medical Sciences Sorkhe Lyzheh- Imam Reza teaching hospital-Office of Women's Education
Kermanshah Iran (Islamic Republic of) 67144-15333 +98 918 387 0264 dr.tayebe_noori@yahoo.com Kermanshah University of Medical Sciences scientific Dr Anisodowleh Nankali
Kermanshah University of Medical Science Sorkhe Lyzheh- Imam Reza teaching hospital-Office of Women's Education
Kermanshah Iran (Islamic Republic of) 67144-15333 +98 83342763018 anis_nankali@yahoo.com Kermanshah University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: all women undergoing abdominal hysterectomy for benign gynecologic disease and Exclusion criteria include patients who have contraindications to misoprostol, including mitral stenosis, heart disease, glaucoma, sickle cell anemia, severe hypertension, diastolic blood pressure above 100 mm /Hg, severe asthma, or known hypersensitivity to prostaglandins, known endometriosis patients with a history of pelvic or active disease, diabetes, obesity (BMI> 30), a history of previous myomectomy and previous use of GnRH agonists before surgery, patients with invasive cancer endometrial, cervical and ovarian tumors. no limit no limit Female XIV Diseas N99-N99 Other disorders of the genitourinary system Placebo Population study Will be divided into two groups. study group(Group 1) and control group (Group 2).In study group 2 pills equal to 400 mcg misoprostol and in control Group 2 pills vitamin B6 will be placed under the tongue one hour before the surgery Blood loss. Timepoint: intra operative. Method of measurement: Total blood volume in the suction bottle + weight difference between dry and wet gauze. Postoperative hemoglobin. Timepoint: 24 hours after surgery. Method of measurement: blood test. Degree of fever after surgery. Timepoint: 24 hours after surgery. Method of measurement: Thermometer. Length of stay in hospital. Timepoint: From admission to exit. Method of measurement: day. The need for blood transfusions. Timepoint: Intraoperative and postoperative. Method of measurement: On hemoglobin level and Severity of bleeding. Vice President of Research   Kermanshah University of Medical Sciences Approved 2015-10-20 Kermanshah University of Medical Sciences Kermanshah -Sorkhe Lyzheh-medical School Kermanshah Iran (Islamic Republic of)