IRCT20190921044828N1 IRCT 2019-09-26 Shahid Beheshti University of Medical Sciences Evaluating the effects of vitamin B1, B6, B12 and folic acid supplementation in women with episodic migraine Evaluating the effects of vitamin B1, B6, B12 and folic acid supplementation versus placebo on serum levels of CGRP, endothelial nitric oxide synthase, homocysteine and headache characteristics in women with episodic migraine 2019-10-23 anticipated 100 Complete https://irct.ir/trial/42399 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients on the basis of random allocation rule method are randomly assigned to the 5 groups; B1, B6, B12, folic acid and placebo. In this study, In this study, 20 codes for each group is placed in a drawing container and then the codes are randomly ejected from the container without replacement and the created sequences are recorded, Blinding description: This study is a double-blind (investigators and patients) trial. For double-blind implementation, at the beginning of the study, all boxes containing B1, B6, B12, folic acid or placebo by a third party (someone other than the researchers) is coded as A, B, C, D and E. 3 migraine headache. Intervention 1: Intervention group: 1. B1(300 mg), 2. B6 (80 mg), 3. B12 (500mcg), 4. folic acid (2mg). Intervention 2: Control group: placebo. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information