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IRCT20110514006481N12 IRCT 2019-10-10 Semnan University of Medical Sciences Effect of Synbiotic on gastrointestinal dysfunction in patients with mechanical ventilation Study of the effect of nutrition with synbiotic compounds on prevention of gastrointestinal dysfunction in patients undergoing mechanical ventilation 2019-10-23 anticipated 60 Complete https://irct.ir/trial/42508 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: Randomization is done using stratified permuted block randomization. Patients are divided into two strata of addicted and non-addicted. For each stratum, a separate random assignment continues to reach the sample size. For random assignment in each stratum, four blocks of (A, B), which include different states of test and control sequences (AABB, ABAB …), are used. Block selection is done according to a random digits table, Blinding description: In this study, the researcher puts the compounds of synbiotic and placebo in two containers marked with the letters A and B. The nurse, patient, and who perform evaluation outcome are unaware of the patient grouping. 3 Patients undergoing mechanical ventilation; Gastrointestinal dysfunction. Intervention 1: Intervention group: Compound of synbiotic (Lactocare) manufacture of Zeist-Takhmir pharmaceutical company, 500 mg twice daily for one week. Intervention 2: Control group: Sugar powder, one teaspoon twice daily for one week. No - There is not a plan to make this available Justification or reason for not sharing IPD is No more information
public Mohsen Soleimani
Semnan university of medical sciences, 5th Km of Damghan road, Semnan, Iran.
Semnan Iran (Islamic Republic of) 3514799442 0098 23 3354192 Soli257@yahoo.com Semnan University of Medical Sciences scientific Mohsen Soleimani
Semnan University of Medical Sciences, 5th Km of Damghan Road
Semnan Iran (Islamic Republic of) 3514799442 +98 23 1335 4192 Soli257@yahoo.com Semnan University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Feeding through nasogastric tube. Mechanical ventilation for at least one week. 30 years 70 years Both Third degree burns Gastrointestinal surgery Multiple organ dysfunction Post cardiac arrest Body mass index more than 35 Liver failure Use of drugs that affect gastrointestinal motility K59 Other functional intestinal disorders Treatment - Drugs Placebo Intervention group: Compound of synbiotic (Lactocare) manufacture of Zeist-Takhmir pharmaceutical company, 500 mg twice daily for one week. Control group: Sugar powder, one teaspoon twice daily for one week. Gastric residual volume. Timepoint: Before intervention and every day for a week. Method of measurement: Measure gastric residual volume with syringe. Intra-abdominal pressure. Timepoint: Before intervention and every day for a week. Method of measurement: Through the urinary catheter by using a ruler. Frequency of defecation. Timepoint: Before intervention and every day for a week. Method of measurement: Count frequency of defecation. Semnan University of Medical Sciences Approved 2019-07-15 Semnan University Of Medical Sciences and Health Services Semnan university of medical sciences, Shahid Akhlaghi intersection, Basij Blvd.,Semnan, Iran. Semnan Semnan Iran (Islamic Republic of)