IRCT20170513033941N65 IRCT 2019-10-14 Kashan University of Medical Sciences Probiotics and brucellosis The effects of probiotics supplementation in the treatment of children with brucellosis 2019-09-03 anticipated 40 Complete https://irct.ir/trial/42614 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients will be randomly assigned into two groups. A randomization list will be generated from 1 to 40 by a random number generator (https://stattrek.com/statistics/random-number-generator.aspx) and patients will be randomly assigned into each intervention group by their numbers. The block randomization technique with 1:1 ratio will be used to achieve balanced group sizes, Blinding description: Randomization and allocation will be concealed from the researchers and participants until the final analyses are completed. Another person at the Pediatric clinic of Shahid Beheshti Hospital, affiliated to Kashan University of Medical Science, who is not involved in the trial and not aware of random sequences, will assign the participants to intervention groups. 3 Brucellosis. Intervention 1: Intervention group: Probiotic capsule (Zisttakhmir Co., Iran) including 2×109 Lactobacillus acidophilus, 2×109 Bifidobacterium bifidum, 2×109 Lactobacillus reuteri, 2×109 Lactobacillus fermentum daily for 8 weeks orally. Intervention 2: Control group: Placebo capsule (Barij essence, Kashan, Iran), daily for 8 weeks orally. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Undecided - It is not yet known if there will be a plan to make this available