IRCT138903114077N1 IRCT 2010-09-10 Royan Institute The comparison of diagnostic open biopsy and needle biopsy in non-obstructive azoospermic patients The comparison of diagnostic TESE and TESA in non-obstructive azoospermic patients 2009-09-15 anticipated 180 Complete https://irct.ir/trial/4265 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 4 male infertility-azoospermia. Intervention 1: Testicular sperm extraction (TESE) Control gurop: A 1.5-2 cm incision was made in the scrotal skin and continued through the tunica albuginea and with a little push somniferous tubule appeared. A testicular biopsy for TESE was taken from (upper, middle and lower pole). Intervention 2: TESA Intervention gurop: In this procedure, a 20 ml syringe with 18 gauge needle was used. At first, we inserted the needle into the upper section of testis and slowly pulled it out to cause negative pressure. For maintaining the negative pressure, we moved the needle in and out of the testis for several times, then pulled the needle out, slowly. This acted as suction and caused the testis tissue to enter into the syringe.Taking biopsies were performed in the upper, middle and lower sections of the testis same as control gurop.